1382489-31-7
1382489-31-7
Chemical Structure
ACP1-01
- CAS 番号: 1382489-31-7
- Formula:C19H18F6N2O3S2
- Molecular Weight:500.48
SMILES: CC(C(NCCSC1=CC=CC=C1C(F)(F)F)=O)(S(=O)(C2=NC=C(C=C2)C(F)(F)F)=O)C
Biological Activity: ACP1-01 is a bacterial ClpP activator with EC50s of 3.4 and 2.6 μM for Neisseria meningitides ClpP (NmClpP) and Escherichia coli ClpP (EcClpP). ACP1-01 noncovalently binds to ClpP C sites and activates the protease. ACP1-01 has antibacterial activity. ACP1-01 can be used for bacterial infections research[1][2].
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ACP1-01 | ACP1-01 is a bacterial ClpP activator with EC50s of 3.4 and 2.6 μM for Neisseria meningitides ClpP (NmClpP) and Escherichia coli ClpP (EcClpP). ACP1-01 noncovalently binds to ClpP C sites and activates the protease. ACP1-01 has antibacterial activity. ACP1-01 can be used for bacterial infections research. | |||||||||||||||||||||
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References
- [1]. Barghash MM, et al. Small molecule dysregulation of ClpP activity via bidirectional allosteric pathways. Structure. 2025 Aug 5:S0969-2126(25)00261-8. [Content Brief]
- [2]. Mabanglo MF, et al. ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores. Commun Biol. 2019 Nov 13;2:410. [Content Brief]
Keywords
