1454651-67-2
1454651-67-2
Chemical Structure
EGFR-IN-180
- CAS 番号: 1454651-67-2
- Formula:C30H38ClN7O3
- Molecular Weight:580.12
InChIKey: BCSHRERPHLTPEE-UHFFFAOYSA-N
SMILES: O=C(C1=C(NC2=NC(NC3=CC=C4C(CCCC(C4)N5CCN(CC5)CCO)=C3OC)=NC=C2Cl)C=CC=C1)NC
Biological Activity: EGFR-IN-180 (Compound L15) is an EGFR inhibitor. EGFR-IN-180 shows inhibitory activity against EFGR and EGFR harboring the L858R/T790M/C797S triple drug-resistant mutation, with IC50 values of 80.96 nM and 16.43 nM, reapectively. EGFR-IN-180 can be used for the study of non-small cell lung cancer (NSCLC)[1].
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EGFR-IN-180 | EGFR-IN-180 (Compound L15) is an EGFR inhibitor. EGFR-IN-180 shows inhibitory activity against EFGR and EGFR harboring the L858R/T790M/C797S triple drug-resistant mutation, with IC50 values of 80.96 nM and 16.43 nM, reapectively. EGFR-IN-180 can be used for the study of non-small cell lung cancer (NSCLC). | |||||||||||||||||||||
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References
Keywords
