1496581-76-0
1496581-76-0
Chemical Structure
GNE-3511
- CAS 番号: 1496581-76-0
- Formula:C23H26F2N6O
- Molecular Weight:440.49
IUPAC Name: 2-((6-(3,3-difluoropyrrolidin-1-yl)-4-(1-(oxetan-3-yl)piperidin-4-yl)pyridin-2-yl)amino)isonicotinonitrile
InChIKey: RHFIAUKMKYHHFA-UHFFFAOYSA-N
SMILES: N#CC1=CC=NC(NC2=NC(N3CC(F)(F)CC3)=CC(C4CCN(C5COC5)CC4)=C2)=C1
Biological Activity: GNE-3511 is an orally active bioavailable and brain-penetrant dual leucine zipper kinase (DLK) inhibitor with a Ki of 0.5 nM. GNE-3511 can cross the blood-brain-barrier and can be used for the research of neurodegenerative diseases[1].
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GNE-3511 | 99.54% | GNE-3511 is an orally active bioavailable and brain-penetrant dual leucine zipper kinase (DLK) inhibitor with a Ki of 0.5 nM. GNE-3511 can cross the blood-brain-barrier and can be used for the research of neurodegenerative diseases. | ||||||||||||||||||||
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References
Keywords
