1911629-44-1
Chemical Structure
Aurora kinase-IN-8
- CAS 番号: 1911629-44-1
- Formula:C25H27N7
- Molecular Weight:425.53
IUPAC Name: (E)-N-(5-methyl-1H-pyrazol-3-yl)-7-(4-methylpiperazin-1-yl)-2-styrylquinazolin-4-amine
InChIKey: DKCSQCAVMRLWQW-DHZHZOJOSA-N
SMILES: CN(CC1)CCN1C(C=C2)=CC3=C2C(NC4=NNC(C)=C4)=NC(/C=C/C5=CC=CC=C5)=N3
Biological Activity: Aurora kinase-IN-8 is a orally active Aurora kinase inhibitor. Aurora kinase-IN-8 shows IC50 values of 2.8 and 28.1 nM against Aurora A kinase and Aurora B kinase. Aurora kinase-IN-8 can prevent spindle formation, cause G2/M phase arrest, and induce cell apoptosis. Aurora kinase-IN-8 can be used for the research of cancer, such as triple-negative breast cancer[1].
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Aurora kinase-IN-8 | Aurora kinase-IN-8 is a orally active Aurora kinase inhibitor. Aurora kinase-IN-8 shows IC50 values of 2.8 and 28.1 nM against Aurora A kinase and Aurora B kinase. Aurora kinase-IN-8 can prevent spindle formation, cause G2/M phase arrest, and induce cell apoptosis. Aurora kinase-IN-8 can be used for the research of cancer, such as triple-negative breast cancer. | |||||||||||||||||||||
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Keywords
