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Cat. No.: HY-175866

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Aurora kinase-IN-8

Aurora kinase-IN-8 is a orally active Aurora kinase inhibitor. Aurora kinase-IN-8 shows IC₅₀ values of 2.8 and 28.1 nM against Aurora A kinase and Aurora B kinase. Aurora kinase-IN-8 can prevent spindle formation, cause G2/M phase arrest, and induce cell apoptosis. Aurora kinase-IN-8 can be used for the research of cancer, such as triple-negative breast cancer.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 1911629-44-1
Formule: C₂₅H₂₇N₇
Masse moléculaire:425.53

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Aurora kinase-IN-8 Chemical Structure

CAS No.: 1911629-44-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

^[1]

Aurora A

2.8 nM (IC₅₀)

Aurora B

28.1 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform Aurora Kinase :

In Vitro

Aurora kinase-IN-8 (Compound 9h) demonstrates superior activity against MDA-MB-231 cells with an IC₅₀ value of 48 nM and 40-560 nM against other cancer cells^[1].
Aurora kinase-IN-8 (1 μM, 48 h) inhibits Aurora A kinase phosphorylation in MDA-MB-231 cells^[1].
Aurora kinase-IN-8 (1 μM, 48 h) prevents spindle formation in MDA-MB-231 cells^[1].
Aurora kinase-IN-8 (0.3-1.2 μM, 24 h) induces G2/M phase arrest and apoptosis in MDA-MB-231 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

MDA-MB-231 cells
Concentration:

1 μM
Incubation Time:

48 h
Result:

Inhibited Aurora A kinase phosphorylation.

Cell Cycle Analysis^[1]

Cell Line:

MDA-MB-231 cells
Concentration:

0.3 and 0.6 μM
Incubation Time:

24 h
Result:

Caused cell cycle G2/M phase arrest and aneuploidy.

In Vivo

Aurora kinase-IN-8 (Compound 9h) (30 mg/kg, i.g., every 2 days for 19 days) significantly inhibits tumor growth in MDA-MB-231 xenograft tumor mice models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

MDA-MB-231 xenograft tumor mice models^[1]
Dosage:

30 mg/kg
Administration:

Orally gavage, every 2 days for 19 days
Result:

Showed a tumor growth inhibition (TGI) rate of 59%.
Reduced tumor weight and volume.
Had no significant impact on mouse body weight and liver/lung weight.

Chemical Information

CAS No. 1911629-44-1
Masse moléculaire 425.53
Formule C₂₅H₂₇N₇
SMILES

CN(CC1)CCN1C(C=C2)=CC3=C2C(NC4=NNC(C)=C4)=NC(/C=C/C5=CC=CC=C5)=N3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Long L, et al. Optimization of Novel Quinazolines as Potent Aurora Kinase Inhibitors for Triple-Negative Breast Cancer Treatment. J Med Chem. 2025 Sep 11;68(17):18197-18215. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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