2446169-48-6
2446169-48-6
Chemical Structure
CAI0019
- CAS 番号: 2446169-48-6
- Formula:C11H18N4O3S2
- Molecular Weight:318.42
InChIKey: YIWUGXRPFUQKLA-UHFFFAOYSA-N
SMILES: O=C(CCC1CCCCC1)NC2=NN=C(S2)S(=O)(N)=O
Biological Activity: CAI0019 is an orally active α-carbonic anhydrase inhibitor based on the Acetazolamide (HY-B0782) framework. CAI0019 exhibits narrow-spectrum antibiofilm activity, with its MIC50 being 0.094 μM and MIC90 being 0.39 μM. CAI0019 selectively inhibits Enterococcus in a septic peritonitis mouse model, without affecting most intestinal commensal bacteria[1].
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CAI0019 | 98.14% | CAI0019 is an orally active α-carbonic anhydrase inhibitor based on the Acetazolamide (HY-B0782) framework. CAI0019 exhibits narrow-spectrum antibiofilm activity, with its MIC50 being 0.094 μM and MIC90 being 0.39 μM. CAI0019 selectively inhibits Enterococcus in a septic peritonitis mouse model, without affecting most intestinal commensal bacteria. | ||||||||||||||||||||
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References
Keywords
