2606032-80-6
Chemical Structure
LIQ1
- CAS 番号: 2606032-80-6
- Formula:C16H12O5
- Molecular Weight:284.26
InChIKey: CRQAOKDMEJPZTH-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CC=C1C2CC(C3=CC=C(C=C3O2)O)=O)O
Biological Activity: LIQ1, a flavonoid derivative, is a potent Pyruvate kinase M2 (PKM2) allosteric inhibitor (IC50 = 0.39 μM; Kd = 4.5 μM) targeting Arg43 within the polyarginine pocket. LIQ1 exhibits efficacy in a mouse model of LPS (HY-D1056)-induced endotoxemia, preventing the nuclear translocation of PKM2 and inhibiting its binding to HIF-1α, thereby suppressing IL-1β transcription. LIQ1 can be used for the research of endotoxemia[1].
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LIQ1 | 97.40% | LIQ1, a flavonoid derivative, is a potent Pyruvate kinase M2 (PKM2) allosteric inhibitor (IC50 = 0.39 μM; Kd = 4.5 μM) targeting Arg43 within the polyarginine pocket. LIQ1 exhibits efficacy in a mouse model of LPS (HY-D1056)-induced endotoxemia, preventing the nuclear translocation of PKM2 and inhibiting its binding to HIF-1α, thereby suppressing IL-1β transcription. LIQ1 can be used for the research of endotoxemia. | ||||||||||||||||||||
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Keywords
