2623-33-8
2623-33-8
Chemical Structure
4-Acetamidophenyl acetate
Synonym(s): Diacetamate
- CAS 番号: 2623-33-8
- Formula:C10H11NO3
- Molecular Weight:193.20
IUPAC Name: 4-acetamidophenyl acetate
InChIKey: UJAOSPFULOFZRR-UHFFFAOYSA-N
SMILES: O=C(C)NC1=CC=C(OC(C)=O)C=C1
Biological Activity: 4-Acetamidophenyl acetate is an impurity of Acetaminophen (HY-66005). 4-Acetamidophenyl acetate acts as an intermediate in the synthesis of Acetaminophen. Acetaminophen is a selective COX-2 inhibitor (IC50=25.8 μM), and is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[1][2][3].
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4-Acetamidophenyl acetate | 97.0% | 4-Acetamidophenyl acetate is an impurity of Acetaminophen (HY-66005). 4-Acetamidophenyl acetate acts as an intermediate in the synthesis of Acetaminophen. Acetaminophen is a selective COX-2 inhibitor (IC50=25.8 μM), and is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor. | ||||||||||||||||||||
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4-Acetamidophenyl acetate (Standard) | ≥98% | 4-Acetamidophenyl acetate (Standard) is the analytical standard of 4-Acetamidophenyl acetate (HY-66004). This product is intended for research and analytical applications. 4-Acetamidophenyl acetate is an impurity of Acetaminophen (HY-66005). 4-Acetamidophenyl acetate acts as an intermediate in the synthesis of Acetaminophen. Acetaminophen is a selective COX-2 inhibitor (IC50=25.8 μM), and is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor. | ||||||||||||||||||||
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References
- [1]. Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J, 2008. 22(2): p. 383-90. [Content Brief]
- [2]. Rothen JP, et al. Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo. Pharmacogenetics. 1998 Dec;8(6):553-9. [Content Brief]
- [3]. Murie V E, et al. Acetaminophen prodrug: microwave-assisted synthesis and in vitro metabolism evaluation by mass spectrometry. Journal of the Brazilian Chemical Society, 2016, 27(6): 1121-1128.
