66258-76-2
Chemical Structure
Piperacillin hydrate
Synonym(s): Pipracil hydrate
- CAS 番号: 66258-76-2
- Formula:C23H29N5O8S
- Molecular Weight:535.57
InChIKey: NBXPLBPWMYNZTC-IDYPWDAWSA-N
SMILES: O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC([C@H](NC(N3C(C(N(CC)CC3)=O)=O)=O)C4=CC=CC=C4)=O)N1C2=O)O.O
Biological Activity: Piperacillin hydrate is a semisynthetic broad-spectrum β-lactam antibiotic which exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins. Piperacillin hydrate is most commonly used in combination with the β-lactamase inhibitor Tazobactam (HY-B1418)[1][2][3].
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Piperacillin hydrate | Piperacillin hydrate is a semisynthetic broad-spectrum β-lactam antibiotic which exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins. Piperacillin hydrate is most commonly used in combination with the β-lactamase inhibitor Tazobactam (HY-B1418). | |||||||||||||||||||||
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- [1]. Fu KP, et al. Piperacillin, a new penicillin active against many bacteria resistant to other penicillins. Antimicrob Agents Chemother. 1978, 13(3):358-67. [Content Brief]
- [2]. Bodey GP, et al. Piperacillin: In Vitro Evaluation. Antimicrob Agents Chemother. 1978, 14(1):78-87. [Content Brief]
- [3]. Harada Y, et al. In vitro and in vivo activities of piperacillin-tazobactam and meropenem at different inoculum sizes of ESBL-producing Klebsiella pneumoniae. Clin Microbiol Infect. 2014, 20(11):O831-9. [Content Brief]
Keywords
