Tbxas1 - thromboxane A synthase 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24886

Summary

Predicted to enable heme binding activity; hydroperoxy icosatetraenoate dehydratase activity; and thromboxane-A synthase activity. Involved in several processes, including cellular chloride ion homeostasis; positive regulation of vasoconstriction; and response to ethanol. Predicted to be located in endoplasmic reticulum membrane. Used to study acute necrotizing pancreatitis; artery disease (multiple); brain infarction; glomerulonephritis (multiple); and thrombosis. Biomarker of hydronephrosis. Human ortholog(s) of this gene implicated in Ghosal hematodiaphyseal syndrome; cerebral infarction; and platelet-type bleeding disorder 14. Orthologous to human TBXAS1 (thromboxane A synthase 1). [provided by Alliance of Genome Resources, Apr 2022]

Tbxas1 Products (1)

mRNA Protein Name
NM_012687.2 NP_036819.1 thromboxane-A synthase

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in intracellular chloride ion homeostasis IMP
IMP: Inferred from mutant phenotype
12023941 RGD
involved in positive regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
9370383 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
9262373 RGD
involved in response to fatty acid IEP
IEP: Inferred from expression pattern
9262373 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thromboxane-A synthase

  • TXA synthase

  • TXS

  • ThromboxA ane synthase 1

  • cytochrome P450 5A1

  • hydroperoxy icosatetraenoate dehydratase

  • thromboxane A synthase 1, platelet

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14286 TBXAS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21954 Tbxas1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28471 Tbxas1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tbxas1 NCBI NCBI:6916