EHD4 - EH domain containing 4 Gene

Also Known as PAST4

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 30844

About EHD4

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:41,895,933-41,972,557 (from NCBI)

This gene has 2 transcripts (splice variants), 205 orthologues and 10 paralogues. Ubiquitous expression in urinary bladder (RPKM 15.6), gall bladder (RPKM 14.3) and 25 other tissues.

Summary

Enables Cadherin binding activity. Involved in endocytic recycling and protein homooligomerization. Located in endoplasmic reticulum and recycling endosome membrane. [provided by Alliance of Genome Resources, Apr 2022]

EHD4 Products (1)

mRNA Protein Name
NM_139265.4 NP_644670.1 EH domain-containing protein 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
17233914 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in endocytic recycling IGI
IGI: Inferred from genetic interaction
17233914 GOA
involved in protein homooligomerization IPI
IPI: Inferred from physical interaction
17233914 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in recycling endosome membrane IDA
IDA: Inferred from direct assay
17233914 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EHD4 Protein Structure

Dynamin_N

Dynamin_N: Dynamin family (64 - 224)

EF-hand_4

EF-hand_4: Cytoskeletal-regulatory complex EF hand (450 - 534)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 541 a.a.
Protein Preferred Names Protein Names

EH domain-containing protein 4

  • PAST homolog 4

関連疾患

Diseases Alias
Ovarian Endometrial Cancer

  • Endometrioid Neoplasm Of Ovary

  • Malignant Ovarian Endometrioid Tumor

  • Ovarian Endometrioid Neoplasm
Cerebral Creatine Deficiency Syndrome 3

  • Arginine:Glycine Amidinotransferase Deficiency

  • Agat Deficiency

  • Gatm Deficiency

  • Creatine Deficiency Syndrome Due To Agat Deficiency

  • L-Arginine:Glycine Amidinotransferase Deficiency

  • CCDS3

  • L-Arginine:Glycine Aminidotransferase Deficiency

  • Deficiency, Cerebral Creatine, Syndrome, Type 3
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-158415 ATPase-IN-4 Inhibitor 98.25% Unkown
HY-RS04224 EHD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16299 Ehd4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28675 Ehd4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Bos taurus EHD4 VGNC VGNC:28374
Mus musculus EHD4 MGD MGI:1919619
Felis catus EHD4 VGNC VGNC:104385
Macaca mulatta EHD4 VGNC VGNC:72177
Rattus norvegicus EHD4 RGD RGD:628883
Canis familiaris EHD4 VGNC VGNC:40248
Others EHD4 NCBI