TJAP1 - tight junction associated protein 1 Gene

Also Known as PILT; TJP4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 93643

About TJAP1

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:43,477,570-43,506,554 (from NCBI)

This gene has 15 transcripts (splice variants) and 85 orthologues. Ubiquitous expression in ovary (RPKM 10.1), endometrium (RPKM 8.8) and 25 other tissues.

Summary

This gene encodes a tight junction-associated protein. Incorporation of the encoded protein into tight junctions occurs at a late stage of formation of the junctions. The encoded protein localizes to the Golgi and may function in vesicle trafficking. Alternatively spliced transcript variants have been described. A related pseudogene exists on the X chromosome. [provided by RefSeq, Mar 2009]

TJAP1 Products (24)

mRNA Protein Name
NM_001146016.2 NP_001139488.1 tight junction-associated protein 1 isoform a
NM_001146017.2 NP_001139489.1 tight junction-associated protein 1 isoform a
NM_001146018.2 NP_001139490.1 tight junction-associated protein 1 isoform b
NM_001146019.2 NP_001139491.1 tight junction-associated protein 1 isoform b
NM_001146020.2 NP_001139492.1 tight junction-associated protein 1 isoform b
NM_001350561.2 NP_001337490.1 tight junction-associated protein 1 isoform a
NM_001350562.2 NP_001337491.1 tight junction-associated protein 1 isoform a
NM_001350563.2 NP_001337492.1 tight junction-associated protein 1 isoform a
NM_001350564.2 NP_001337493.1 tight junction-associated protein 1 isoform a
NM_001350565.2 NP_001337494.1 tight junction-associated protein 1 isoform a
NM_001350566.2 NP_001337495.1 tight junction-associated protein 1 isoform a
NM_001350567.2 NP_001337496.1 tight junction-associated protein 1 isoform a
NM_001350568.2 NP_001337497.1 tight junction-associated protein 1 isoform a
NM_001350569.2 NP_001337498.1 tight junction-associated protein 1 isoform b
NM_001350570.2 NP_001337499.1 tight junction-associated protein 1 isoform b
NM_001394538.1 NP_001381467.1 tight junction-associated protein 1 isoform c
NM_001394539.1 NP_001381468.1 tight junction-associated protein 1 isoform c
NM_001394540.1 NP_001381469.1 tight junction-associated protein 1 isoform d
NM_001394541.1 NP_001381470.1 tight junction-associated protein 1 isoform d
NM_001394542.1 NP_001381471.1 tight junction-associated protein 1 isoform d
NM_001394543.1 NP_001381472.1 tight junction-associated protein 1 isoform d
NM_001394544.1 NP_001381473.1 tight junction-associated protein 1 isoform d
NM_001394545.1 NP_001381474.1 tight junction-associated protein 1 isoform d
NM_080604.3 NP_542171.2 tight junction-associated protein 1 isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TJAP1 Protein Structure

Pilt

Pilt: Protein incorporated later into Tight Junctions (266 - 556)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 557 a.a.
Protein Preferred Names Protein Names

tight junction-associated protein 1

  • protein incorporated later into tight junctions

TJAP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TJAP1 Q5JTD0 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
TJAP1 Q5JTD0 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
TJAP1 Q5JTD0 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
TJAP1 Q5JTD0 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
32296183
Intra
TJAP1 Q5JTD0 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
32296183
Intra
TJAP1 Q5JTD0 TRIM54 Homo sapiens Q9BYV2
Y2H Array
32296183
Intra
TJAP1 Q5JTD0 KRT75 Homo sapiens O95678
Y2H Prey Pooling
32296183
Intra
TJAP1 Q5JTD0 KRT75 Homo sapiens O95678
Y2H Array
32296183
Intra
TJAP1 Q5JTD0 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra
TJAP1 Q5JTD0 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Siberian Tick Typhus

  • North Asian Tick Typhus

  • Manchurian Typhus

  • North Asian Tick Fever

  • Rickettsia Sibirica Spotted Fever

  • Spotted Fever Group Rickettsiosis
Fallopian Tube Disease

  • Fallopian Tube Diseases
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14552 TJAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TJAP1 VGNC VGNC:47385
Bos taurus TJAP1 VGNC VGNC:35880
Macaca mulatta TJAP1 VGNC VGNC:78407
Mus musculus TJAP1 MGD MGI:1921344
Felis catus TJAP1 VGNC VGNC:66198
Rattus norvegicus TJAP1 RGD RGD:1308708
Others TJAP1 NCBI