TJAP1 - tight junction associated protein 1 Gene

Homo sapiens

Also known as PILT; TJP4

Gene ID: 93643 | Gene type: protein coding

About TJAP1

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:43,477,570-43,506,554 (from NCBI)

This gene has 15 transcripts (splice variants) and 85 orthologues. Ubiquitous expression in ovary (RPKM 10.1), endometrium (RPKM 8.8) and 25 other tissues.

Summary

This gene encodes a tight junction-associated protein. Incorporation of the encoded protein into tight junctions occurs at a late stage of formation of the junctions. The encoded protein localizes to the Golgi and may function in vesicle trafficking. Alternatively spliced transcript variants have been described. A related pseudogene exists on the X chromosome. [provided by RefSeq, Mar 2009]

TJAP1 Products(24)

mRNA	Protein	Name
NM_001146016.2	NP_001139488.1	tight junction-associated protein 1 isoform a
NM_001146017.2	NP_001139489.1	tight junction-associated protein 1 isoform a
NM_001146018.2	NP_001139490.1	tight junction-associated protein 1 isoform b
NM_001146019.2	NP_001139491.1	tight junction-associated protein 1 isoform b
NM_001146020.2	NP_001139492.1	tight junction-associated protein 1 isoform b
NM_001350561.2	NP_001337490.1	tight junction-associated protein 1 isoform a
NM_001350562.2	NP_001337491.1	tight junction-associated protein 1 isoform a
NM_001350563.2	NP_001337492.1	tight junction-associated protein 1 isoform a
NM_001350564.2	NP_001337493.1	tight junction-associated protein 1 isoform a
NM_001350565.2	NP_001337494.1	tight junction-associated protein 1 isoform a
NM_001350566.2	NP_001337495.1	tight junction-associated protein 1 isoform a
NM_001350567.2	NP_001337496.1	tight junction-associated protein 1 isoform a
NM_001350568.2	NP_001337497.1	tight junction-associated protein 1 isoform a
NM_001350569.2	NP_001337498.1	tight junction-associated protein 1 isoform b
NM_001350570.2	NP_001337499.1	tight junction-associated protein 1 isoform b
NM_001394538.1	NP_001381467.1	tight junction-associated protein 1 isoform c
NM_001394539.1	NP_001381468.1	tight junction-associated protein 1 isoform c
NM_001394540.1	NP_001381469.1	tight junction-associated protein 1 isoform d
NM_001394541.1	NP_001381470.1	tight junction-associated protein 1 isoform d
NM_001394542.1	NP_001381471.1	tight junction-associated protein 1 isoform d
NM_001394543.1	NP_001381472.1	tight junction-associated protein 1 isoform d
NM_001394544.1	NP_001381473.1	tight junction-associated protein 1 isoform d
NM_001394545.1	NP_001381474.1	tight junction-associated protein 1 isoform d
NM_080604.3	NP_542171.2	tight junction-associated protein 1 isoform b

TJAP1 Protein Structure

Pilt

0
100
200
300
400
500
557 a.a.

Protein Preferred Names

Protein Names

tight junction-associated protein 1

protein incorporated later into tight junctions

Related Diseases

Diseases

Alias

Siberian Tick Typhus

North Asian Tick Typhus	Manchurian Typhus
North Asian Tick Fever	Rickettsia Sibirica Spotted Fever
Spotted Fever Group Rickettsiosis

Fallopian Tube Disease

Fallopian Tube Diseases

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14552	TJAP1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TJAP1	VGNC	VGNC:47385
Bos taurus	TJAP1	VGNC	VGNC:35880
Macaca mulatta	TJAP1	VGNC	VGNC:78407
Mus musculus	TJAP1	MGD	MGI:1921344
Felis catus	TJAP1	VGNC	VGNC:66198
Rattus norvegicus	TJAP1	RGD	RGD:1308708

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