3109982-48-8
3109982-48-8
Chemical Structure
SGK1-IN-8
- CAS No.: 3109982-48-8
- Formula:C18H13ClN4O
- Molecular Weight:336.78
InChIKey: YNMVSXLHCBQXOW-UHFFFAOYSA-N
SMILES: O=C(C1=CNC=C1C2=CC=C(Cl)C=C2)NC3=CC4=C(NN=C4)C=C3
Biological Activity: SGK1-IN-8 (compound 55) is a SGK1 and GSK3β inhibitor, with an IC50 of 0.11 μM against human SGK1 and an IC50 of 3.39 μM against human GSK3β. SGK1-IN-8 inhibits the catalytic activities of SGK1 and GSK3β, and reduces the phosphorylation level of TAU protein at the Ser214 site. SGK1-IN-8 is available for the research of Alzheimer's disease[1].
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SGK1-IN-8 | SGK1-IN-8 (compound 55) is a SGK1 and GSK3β inhibitor, with an IC50 of 0.11 μM against human SGK1 and an IC50 of 3.39 μM against human GSK3β. SGK1-IN-8 inhibits the catalytic activities of SGK1 and GSK3β, and reduces the phosphorylation level of TAU protein at the Ser214 site. SGK1-IN-8 is available for the research of Alzheimer's disease. | |||||||||||||||||||||
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References
Keywords
