3113123-63-7
3113123-63-7
Chemical Structure
PROTAC AAK1 degrader-1
- CAS No.: 3113123-63-7
- Formula:C48H56F3N7O4
- Molecular Weight:852.00
InChIKey: JHFOCTQMLBEBAO-XPELXJMBSA-N
SMILES: CC(C[C@@H](COC1=CC=C(C=C1C(F)(F)F)C2=CC(NC3=CC=C(C=C3)C4CCN(CC4)CC5CCN(CC5)C6=CC7=C(C(N(C7)C8CCC(NC8=O)=O)=O)C=C6)=NC=C2)N)C
Biological Activity: PROTAC AAK1 degrader-1 (compound 14) is a selective PROTAC AAK1 degrader with a DC50 of <10 nM. PROTAC AAK1 degrader-1 does not significantly impact the levels of any other NAK family members, including BMP2K, GAK, and STK16. PROTAC AAK1 degrader-1 can be used in ovarian cancer research[1].
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PROTAC AAK1 degrader-1 | PROTAC AAK1 degrader-1 (compound 14) is a selective PROTAC AAK1 degrader with a DC50 of <10 nM. PROTAC AAK1 degrader-1 does not significantly impact the levels of any other NAK family members, including BMP2K, GAK, and STK16. PROTAC AAK1 degrader-1 can be used in ovarian cancer research. | |||||||||||||||||||||
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References
Keywords
