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Tgfbr3 - transforming growth factor, beta receptor III Gene

Also Known as TBRIII; 1110036H20Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 21814

About Tgfbr3

Chromosome 5: 107,254,436-107,437,495 reverse strand.GRCm39:CM000998.3

This gene has 4 transcripts (splice variants), 203 orthologues, 2 paralogues and is associated with 52 phenotypes. Broad expression in adrenal adult (RPKM 38.6), bladder adult (RPKM 2.1) and 2 other tissues.

Summary

Enables several functions, including PDZ domain binding activity; transforming growth factor beta binding activity; and transforming growth factor beta-activated receptor activity. Involved in several processes, including definitive erythrocyte differentiation; heart development; and transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and vasculogenesis. Located in cell surface and endoplasmic reticulum. Is expressed in several structures, including brain; early conceptus; heart; lower jaw; and ovary. Orthologous to human TGFBR3 (transforming growth factor beta receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Tgfbr3 Products (1)

mRNA	Protein	Name
NM_011578.4	NP_035708.2	transforming growth factor beta receptor type 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	11546783	MGI
enables SMAD binding	IMP IMP: Inferred from mutant phenotype	17295310	MGI
enables glycosaminoglycan binding	IDA IDA: Inferred from direct assay	12773577	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12773577	MGI
enables transforming growth factor beta binding	IDA IDA: Inferred from direct assay	17295310	MGI
enables transforming growth factor beta receptor activity	IDA IDA: Inferred from direct assay	9659379	MGI
enables transforming growth factor beta receptor activity	IMP IMP: Inferred from mutant phenotype	17823118	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	25382630	MGI
acts upstream of apoptotic process involved in morphogenesis	IMP IMP: Inferred from mutant phenotype	25382630	MGI
acts upstream of or within blastocyst development	IDA IDA: Inferred from direct assay	9921650	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	17704211	MGI
acts upstream of or within blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	25382630	MGI
involved in cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	12773577	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	25382630	MGI
involved in collagen metabolic process	IGI IGI: Inferred from genetic interaction	22960625	MGI
involved in definitive erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	12773577	MGI
involved in definitive hemopoiesis	IMP IMP: Inferred from mutant phenotype	12773577	MGI
involved in epicardium-derived cardiac fibroblast cell development	IMP IMP: Inferred from mutant phenotype	17704211	MGI
involved in heart trabecula formation	IMP IMP: Inferred from mutant phenotype	12773577	MGI
involved in heart trabecula morphogenesis	IMP IMP: Inferred from mutant phenotype	12773577	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	17704211	MGI
involved in liver development	IMP IMP: Inferred from mutant phenotype	12773577	MGI
involved in muscular septum morphogenesis	IMP IMP: Inferred from mutant phenotype	12773577	MGI
acts upstream of or within negative regulation of apoptotic process involved in morphogenesis	IMP IMP: Inferred from mutant phenotype	25382630	MGI
acts upstream of or within negative regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	17823118	MGI
involved in negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	17295310	MGI
acts upstream of or within negative regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	17823118	MGI
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	22960625	MGI
acts upstream of or within osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	25382630	MGI
involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	17704211	MGI
acts upstream of or within positive regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	25382630	MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	17823118	MGI
involved in positive regulation of SMAD protein signal transduction	IMP IMP: Inferred from mutant phenotype	17295310	MGI
involved in positive regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	12773577	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	25382630	MGI
acts upstream of or within positive regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25382630	MGI
NOT involved in regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	12773577	MGI
NOT involved in regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	12773577	MGI
acts upstream of or within roof of mouth development	IMP IMP: Inferred from mutant phenotype	25382630	MGI
involved in secondary palate development	IMP IMP: Inferred from mutant phenotype	17295310	MGI
involved in transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	11546783	MGI
involved in transforming growth factor beta receptor signaling pathway	IGI IGI: Inferred from genetic interaction	12773577	MGI
acts upstream of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25382630	MGI
acts upstream of or within vasculogenesis	IMP IMP: Inferred from mutant phenotype	25382630	MGI
involved in vasculogenesis involved in coronary vascular morphogenesis	IMP IMP: Inferred from mutant phenotype	17704211	MGI
involved in ventricular cardiac muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	12773577	MGI
involved in ventricular compact myocardium morphogenesis	IMP IMP: Inferred from mutant phenotype	12773577	MGI
involved in ventricular septum morphogenesis	IMP IMP: Inferred from mutant phenotype	17704211	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	11546783	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	9921650	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	9921650	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tgfbr3 Protein Structure

0
200
400
600
800
850 a.a.

Protein Preferred Names	Protein Names
transforming growth factor beta receptor type 3	TGF-beta receptor type 3 TGF-beta receptor type III TGFR-3 betaglycan

Recombinant Tgfbr3 Proteins

Cat. No.	상품명	Accession	Purity
HY-P72452	TGFBR3/TGF-beta RIII Protein, Mouse (HEK293, His)	A0A0R4J097 (G23-T785)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS14450	TGFBR3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14451	Tgfbr3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14452	Tgfbr3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14453	TGFBR3L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174529	Human TGFBR3 mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tgfbr3	NCBI	NCBI:7049