Slc4a2 - solute carrier family 4 member 2 Gene

Also Known as Ae2; Aep2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24780

Summary

Enables enzyme binding activity. Involved in digestive tract development; regulation of intracellular pH; and spermatogenesis. Located in apical plasma membrane and basolateral plasma membrane. Biomarker of autosomal recessive polycystic kidney disease and prediabetes syndrome. Orthologous to human SLC4A2 (solute carrier family 4 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc4a2 Products (1)

mRNA Protein Name
NM_017048.2 NP_058744.1 anion exchange protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chloride:bicarbonate antiporter activity IDA
IDA: Inferred from direct assay
2371270 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
17652430 RGD
Biological Process GO Annotation Evidence References Source
involved in digestive tract development IEP
IEP: Inferred from expression pattern
8770049 RGD
involved in regulation of intracellular pH IMP
IMP: Inferred from mutant phenotype
16440368 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
10491633 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
22310983 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
10600827 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

anion exchange protein 2

  • AE 2

  • AE2 Cl-/HCO3-exchanger, variant AE2b

  • B3RP-2

  • Solute carrier family 4, member 2, anion exchange protein 2

  • anion exchanger 2

  • band 3-related protein 2

  • non-erythroid band 3-like protein

  • solute carrier family 4 (anion exchanger), member 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-180371 NF-115 Inducer / Unkown
HY-RS13268 SLC4A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc4a2 NCBI NCBI:6522