NF-115 

NF-115 is a glycolipid and Neurostatin analog. NF-115 inhibits the expression of the ARHGDIA gene and alters the biosynthetic pathway of glycosphingolipids. NF-115 induces Apoptosis. NF-115 exhibits anticancer activity against glioma. NF-115 can be used in research related to glioma, glioblastoma and neuroectodermal tumors^[1][2][3].

NF-115 (43 µM) inhibits the proliferation of human U-373 glioma cells (ID₅₀ = 43 μM)^[1].
NF-115 (180 μM) inhibits proliferation of U373-MG human astrocytoma cells with an ID₅₀ of 180 μM^[3].
NF-115 alters gene expression in U373-MG human glioblastoma cells, repressing 491 genes and up-regulating 76 genes, including specific repression of ARHGDIA, SLC4A2, YWHAE, TP53, and BCL2L1 with fold changes ranging from -0.3 to -0.7 relative to untreated controls^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NF-115 (administered intratumorally; once daily; for 15 consecutive days) eliminates glioma in the N-ethyl-N-nitrosourea (HY-W019815)-induced primitive neuroectodermal tumor model in rats^[1].
NF-115 disrupts astrocytomas implanted in immunodeficient mice^[2].
NF-115 disrupts neuroectodermal tumors implanted in rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

451.56

C₂₁H₄₁NO₉

368870-53-5

O(CCCCCCCC)[C@@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](COCC(CO)(CO)CO)O1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Nieto-Sampedro M, et al. Natural, synthetic and semisynthetic glycolipid inhibitors of glioma growth. Expert Opin Ther Pat. 2004;14(4):487-497.  [Content Brief]

  [2]. Nieto-Sampedro M, et al. Natural, synthetic and semisynthetic glycolipid inhibitors of glioma growth. Expert Opin Ther Pat. 2004 Apr;14(4):487-97.  [Content Brief]

  [3]. Doncel-Pérez E, et al. Synthetic glycolipids for glioma growth inhibition developed from neurostatin and NF115 compound. Bioorg Med Chem Lett. 2013 Jan 15;23(2):435-9.  [Content Brief]