368870-53-5
Chemical Structure
NF-115
- CAS No.: 368870-53-5
- Formula:C21H41NO9
- Molecular Weight:451.56
IUPAC Name: N-((2S,3R,4R,5S,6R)-4,5-dihydroxy-6-((3-hydroxy-2,2-bis(hydroxymethyl)propoxy)methyl)-2-(octyloxy)tetrahydro-2H-pyran-3-yl)acetamide
InChIKey: RTZVGRDKIWCYBJ-WAPOTWQKSA-N
SMILES: O(CCCCCCCC)[C@@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](COCC(CO)(CO)CO)O1
Biological Activity: NF-115 is a glycolipid and Neurostatin analog. NF-115 inhibits the expression of the ARHGDIA gene and alters the biosynthetic pathway of glycosphingolipids. NF-115 induces Apoptosis. NF-115 exhibits anticancer activity against glioma. NF-115 can be used in research related to glioma, glioblastoma and neuroectodermal tumors[1][2][3].
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NF-115 | NF-115 is a glycolipid and Neurostatin analog. NF-115 inhibits the expression of the ARHGDIA gene and alters the biosynthetic pathway of glycosphingolipids. NF-115 induces Apoptosis. NF-115 exhibits anticancer activity against glioma. NF-115 can be used in research related to glioma, glioblastoma and neuroectodermal tumors. | |||||||||||||||||||||
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References
- [1]. Nieto-Sampedro M, et al. Natural, synthetic and semisynthetic glycolipid inhibitors of glioma growth. Expert Opin Ther Pat. 2004;14(4):487-497. [Content Brief]
- [2]. Nieto-Sampedro M, et al. Natural, synthetic and semisynthetic glycolipid inhibitors of glioma growth. Expert Opin Ther Pat. 2004 Apr;14(4):487-97. [Content Brief]
- [3]. Doncel-Pérez E, et al. Synthetic glycolipids for glioma growth inhibition developed from neurostatin and NF115 compound. Bioorg Med Chem Lett. 2013 Jan 15;23(2):435-9. [Content Brief]
