N-Ethyl-N-nitrosourea
Based on 1 Customer Validation
N-Ethyl-N-nitrosourea (ENU) is a DNA alkylating agent. N-Ethyl-N-nitrosourea induces leukemia by alkylating nucleobases, disrupting DNA, and resulting in bone marrow suppression and the formation of leukemic cells. N-Ethyl-N-nitrosourea is teratogenic in vivo, inducing tumor formation and paw malformations in pregnant rats. N-Ethyl-N-nitrosourea cause central nervous system (CNS) tumors and genetic disorders.
For research use only. We do not sell to patients.
- Purity: 99.92%
- CAS No.: 759-73-9
- Formula: C3H7N3O2
- Molecular Weight:117.11
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Storage:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 759-73-9
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Appearance Solid
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Molecular Weight 117.11
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Formula C3H7N3O2
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Color Off-white to pink
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SMILES
O=NN(CC)C(N)=O
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Synonyms
ENU; N-Nitroso-N-ethylurea
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 116.67 mg/mL (996.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (645 KB)
- English - EN (645 KB)
- Français - FR (645 KB)
- Deutsch - DE (645 KB)
- Norwegian - NO (645 KB)
- Español - ES (645 KB)
- Swedish - SV (645 KB)
- Italian - IT (645 KB)
- Korean - KR (645 KB)
- Portuguese - PT (645 KB)
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Handling Instructions (2659 KB)
References
[1]. Hou X, et al. N-Ethyl-N-Nitrosourea Induced Leukaemia in a Mouse Model: Protective Effect of Icaritin via Inhibition of IL-6/JAK2/STAT3 Pathway Causes Apoptosis. J Inflamm Res. 2024 Feb 7;17:777-790. [Content Brief]
[2]. Goth R, et al. Persistence of O6-ethylguanine in rat-brain DNA: correlation with nervous system-specific carcinogenesis by ethylnitrosourea. Proc Natl Acad Sci U S A. 1974 Mar;71(3):639-43. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 8.5390 mL | 42.6949 mL | 85.3898 mL | 213.4745 mL |
| 5 mM | 1.7078 mL | 8.5390 mL | 17.0780 mL | 42.6949 mL | |
| 10 mM | 0.8539 mL | 4.2695 mL | 8.5390 mL | 21.3475 mL | |
| 15 mM | 0.5693 mL | 2.8463 mL | 5.6927 mL | 14.2316 mL | |
| 20 mM | 0.4269 mL | 2.1347 mL | 4.2695 mL | 10.6737 mL | |
| 25 mM | 0.3416 mL | 1.7078 mL | 3.4156 mL | 8.5390 mL | |
| 30 mM | 0.2846 mL | 1.4232 mL | 2.8463 mL | 7.1158 mL | |
| 40 mM | 0.2135 mL | 1.0674 mL | 2.1347 mL | 5.3369 mL | |
| 50 mM | 0.1708 mL | 0.8539 mL | 1.7078 mL | 4.2695 mL | |
| 60 mM | 0.1423 mL | 0.7116 mL | 1.4232 mL | 3.5579 mL | |
| 80 mM | 0.1067 mL | 0.5337 mL | 1.0674 mL | 2.6684 mL | |
| 100 mM | 0.0854 mL | 0.4269 mL | 0.8539 mL | 2.1347 mL |
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