759-73-9
Chemical Structure
N-Ethyl-N-nitrosourea
Synonym(s): ENU; N-Nitroso-N-ethylurea
- CAS No.: 759-73-9
- Formula:C3H7N3O2
- Molecular Weight:117.11
IUPAC Name: 1-ethyl-1-nitrosourea
InChIKey: FUSGACRLAFQQRL-UHFFFAOYSA-N
SMILES: O=NN(CC)C(N)=O
Biological Activity: N-Ethyl-N-nitrosourea (ENU) is a DNA alkylating agent. N-Ethyl-N-nitrosourea induces leukemia by alkylating nucleobases, disrupting DNA, and resulting in bone marrow suppression and the formation of leukemic cells. N-Ethyl-N-nitrosourea is teratogenic in vivo, inducing tumor formation and paw malformations in pregnant rats. N-Ethyl-N-nitrosourea cause central nervous system (CNS) tumors and genetic disorders[1][2].
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N-Ethyl-N-nitrosourea | 99.92% | N-Ethyl-N-nitrosourea (ENU) is a DNA alkylating agent. N-Ethyl-N-nitrosourea induces leukemia by alkylating nucleobases, disrupting DNA, and resulting in bone marrow suppression and the formation of leukemic cells. N-Ethyl-N-nitrosourea is teratogenic in vivo, inducing tumor formation and paw malformations in pregnant rats. N-Ethyl-N-nitrosourea cause central nervous system (CNS) tumors and genetic disorders. | ||||||||||||||||||||
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- [1]. Hou X, et al. N-Ethyl-N-Nitrosourea Induced Leukaemia in a Mouse Model: Protective Effect of Icaritin via Inhibition of IL-6/JAK2/STAT3 Pathway Causes Apoptosis. J Inflamm Res. 2024 Feb 7;17:777-790. [Content Brief]
- [2]. Goth R, et al. Persistence of O6-ethylguanine in rat-brain DNA: correlation with nervous system-specific carcinogenesis by ethylnitrosourea. Proc Natl Acad Sci U S A. 1974 Mar;71(3):639-43. [Content Brief]
Keywords
