PTPRO - protein tyrosine phosphatase receptor type O Gene

Also Known as NPHS6; PTPU2; GLEPP1; PTP-OC; PTP-U2; PTPROT; R-PTP-O

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5800

About PTPRO

Cytogenetic location: 12p12.3 Genomic coordinates (GRCh38): 12:15,322,508-15,598,331 (from NCBI)

This gene has 26 transcripts (splice variants), 220 orthologues, 35 paralogues and is associated with 2 phenotypes. Biased expression in kidney (RPKM 3.7), brain (RPKM 2.7) and 11 other tissues.

Summary

This gene encodes a member of the R3 subtype family of receptor-type Protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of Apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of Cancer. [provided by RefSeq, May 2011]

PTPRO Products (6)

mRNA	Protein	Name
NM_002848.4	NP_002839.1	receptor-type tyrosine-protein phosphatase O isoform b precursor
NM_030667.3	NP_109592.1	receptor-type tyrosine-protein phosphatase O isoform a precursor
NM_030668.3	NP_109593.1	receptor-type tyrosine-protein phosphatase O isoform d
NM_030669.3	NP_109594.1	receptor-type tyrosine-protein phosphatase O isoform c
NM_030670.3	NP_109595.1	receptor-type tyrosine-protein phosphatase O isoform d
NM_030671.3	NP_109596.1	receptor-type tyrosine-protein phosphatase O isoform c

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables cadherin binding	IPI IPI: Inferred from physical interaction	28926625	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19167335	GOA
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	19167335	GOA
enables protein tyrosine phosphatase activity	IMP IMP: Inferred from mutant phenotype	19233845	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in glomerulus development	IMP IMP: Inferred from mutant phenotype	21722858	GOA
involved in monocyte chemotaxis	IMP IMP: Inferred from mutant phenotype	19233845	GOA
involved in peptidyl-tyrosine dephosphorylation	IMP IMP: Inferred from mutant phenotype	19233845	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPRO Protein Structure

fn3

Y_phosphatase

0
200
400
600
800
1000
1216 a.a.

Protein Preferred Names	Protein Names
receptor-type tyrosine-protein phosphatase O	PTP phi

PTPRO Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PTPRO	Q16827	MET	Homo sapiens	P08581	Phosphatase Assay	19167335
Intra	PTPRO	Q16827	MET	Homo sapiens	P08581	Pull Down	28330616

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Nephrotic Syndrome, Type 6	NPHS6 Nephrotic Syndrome Type 6 Nephrotic Syndrome 6
Genetic Steroid-Resistant Nephrotic Syndrome	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Genetic Srns Hereditary Steroid-Resistant Nephrotic Syndrome Familial Idiopathic Nephrotic Syndrome Nephrotic Syndrome, Steroid-Resistant, Autosomal Recessive Srn1
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Focal Segmental Glomerulosclerosis 7	FSGS7 Glomerulosclerosis, Focal Segmental, 7 Glomerulosclerosis, Focal Segmental, Type 7
Focal Segmental Glomerulosclerosis 9	FSGS9 Glomerulosclerosis, Focal Segmental, 9 Glomerulosclerosis, Focal Segmental, Type 9
Familial Nephrotic Syndrome	Congenital Nephrotic Syndrome Nephrosis, Congenital Finnish Congenital Nephrotic Syndrome
Galloway-Mowat Syndrome	Galloway Mowat Syndrome Galloway Syndrome Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type Microcephaly Nephrosis Syndrome Microcephaly, Hiatal Hernia, And Nephrotic Syndrome Nephrosis Neuronal Dysmigration Syndrome Microcephaly-Hiatus Hernia-Nephrotic Syndrome Nephrosis-Neuronal Dysmigration Syndrome
Alport Syndrome	Hereditary Nephritis Alport Syndrome, X-Linked Hemorrhagic Hereditary Nephritis Congenital Hereditary Hematuria Hemorrhagic Familial Nephritis Familial Nephritis Thin Basement Membrane Disease Thin Basement Membrane Nephropathy Hematuria-Nephropathy-Deafness Syndrome Hematuric Hereditary Nephritis Hereditary Familial Congenital Hemorrhagic Nephritis Hereditary Hematuria Syndrome Hereditary Interstitial Pyelonephritis Alport Deafness-Nephropathy Alport Hearing Loss-Nephropathy Alports Syndrome Nephritis, Hereditary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-N1966	(E)-Osmundacetone		99.81%	Unkown
HY-183573	PTPRO-IN-1	Inhibitor	/	Unkown
HY-RS11446	PTPRO Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11451	PTPRU Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PTPRO	VGNC	VGNC:45195
Macaca mulatta	PTPRO	VGNC	VGNC:100096
Bos taurus	PTPRO	VGNC	VGNC:33555
Felis catus	PTPRO	VGNC	VGNC:69179
Rattus norvegicus	PTPRO	RGD	RGD:62068
Mus musculus	PTPRO	MGD	MGI:1097152
Others	PTPRO	NCBI