USP46 - ubiquitin specific peptidase 46 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64854

About USP46

Cytogenetic location: 4q12 Genomic coordinates (GRCh38): 4:52,590,960-52,659,301 (from NCBI)

This gene has 9 transcripts (splice variants), 211 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 11.8), heart (RPKM 7.4) and 23 other tissues.

Summary

Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating Enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating Enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Jun 2009]

USP46 Products (4)

mRNA Protein Name
NM_001134223.2 NP_001127695.1 ubiquitin carboxyl-terminal hydrolase 46 isoform 2
NM_001286767.2 NP_001273696.1 ubiquitin carboxyl-terminal hydrolase 46 isoform 3
NM_001286768.2 NP_001273697.1 ubiquitin carboxyl-terminal hydrolase 46 isoform 4
NM_022832.4 NP_073743.2 ubiquitin carboxyl-terminal hydrolase 46 isoform 1

USP46 Protein Structure

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (34 - 362)

  • 0
  • 100
  • 200
  • 300
  • 366 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 46

  • deubiquitinating enzyme 46

USP46 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
USP46 P62068 WDR20 Homo sapiens Q8TBZ3
Y2H Prey Pooling
32296183
Intra
USP46 P62068 WDR20 Homo sapiens Q8TBZ3
Validated Y2H
32296183
Intra
USP46 P62068 WDR20 Homo sapiens Q8TBZ3
Anti Tag CoIP
19615732
Intra
USP46 P62068 WDR20 Homo sapiens Q8TBZ3
Y2H Array
32296183
Intra
USP46 P62068 WDR20 Homo sapiens Q8TBZ3
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

USP46 Antibodies

Cat. No. 상품명 신청 Reactivity
HY-P811328 USP46 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS24179 Usp46 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15557 USP46 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17714 Usp46 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus USP46 VGNC VGNC:66889
Bos taurus USP46 VGNC VGNC:52847
Macaca mulatta USP46 VGNC VGNC:79229
Rattus norvegicus USP46 RGD RGD:1564808
Mus musculus USP46 MGD MGI:1916977
Canis familiaris USP46 VGNC VGNC:51784
Others USP46 NCBI