USP46 Antibody
(Synonyms: Ubiquitin carboxyl-terminal hydrolase 46, Deubiquitinating enzyme 46, Ubiquitin thioesterase 46, Ubiquitin-specific-processing protease 46, USP46)
Based on 1 Customer Validation
USP46 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to USP46.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:50-200 | 1:50-200 |
Product Details
USP46 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to USP46.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 50 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 26 kDa & 41 kDa & 42 kDa
Synthetic peptide of human USP46.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
USP46 is a Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2[1][2].
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Subcellular Localization
Cytoplasm
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Expression
Tissue_Specificity: Broadly expressed. -
Isoforms & Post-Translational Modification
USP46 has 4 isoforms, P62068-1: amino acid length is 366, molecular weight is 42442 Da (predicted); P62068-2: amino acid length is 225, molecular weight is 26243 Da (predicted); P62068-3: amino acid length is 359, molecular weight is 41732 Da (predicted); P62068-4: amino acid length is 354, molecular weight is 41112 Da (predicted).USP46 存在 4 个异构体，P62068-1：氨基酸个数为 366 个，分子量为 42442 Da (预测)；P62068-2：氨基酸个数为 225 个，分子量为 26243 Da (预测)；P62068-3：氨基酸个数为 359 个，分子量为 41732 Da (预测)；P62068-4：氨基酸个数为 354 个，分子量为 41112 Da (预测)。
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Subunit
Interacts with WDR48.
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SwissProt ID
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Synonyms
Ubiquitin carboxyl-terminal hydrolase 46, Deubiquitinating enzyme 46, Ubiquitin thioesterase 46, Ubiquitin-specific-processing protease 46, USP46
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