SLC9A1 - solute carrier family 9 member A1 Gene

Also Known as APNH; NHE1; LIKNS; NHE-1; PPP1R143

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6548

About SLC9A1

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:27,098,809-27,155,125 (from NCBI)

This gene has 6 transcripts (splice variants), 276 orthologues, 10 paralogues and is associated with 2 phenotypes. Ubiquitous expression in stomach (RPKM 26.5), salivary gland (RPKM 13.2) and 23 other tissues.

Summary

This gene encodes a Na+/H+ antiporter that is a member of the solute carrier family 9. The encoded protein is a plasma membrane transporter that is expressed in the kidney and intestine. This protein plays a central role in regulating pH homeostasis, cell migration and cell volume. This protein may also be involved in tumor growth. [provided by RefSeq, Sep 2011]

SLC9A1 Products (1)

mRNA	Protein	Name
NM_003047.5	NP_003038.2	sodium/hydrogen exchanger 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium-dependent protein binding	IDA IDA: Inferred from direct assay	15035633	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	17073455	GOA
enables phospholipid binding	IDA IDA: Inferred from direct assay	22020933	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8901634	GOA
enables protein phosphatase 2B binding	IDA IDA: Inferred from direct assay	22688515	GOA
enables protein phosphatase 2B binding	IPI IPI: Inferred from physical interaction	22688515	GOA
enables sodium:proton antiporter activity	IDA IDA: Inferred from direct assay	2536298	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to acidic pH	IDA IDA: Inferred from direct assay	24840010	GOA
involved in cellular response to epinephrine stimulus	IMP IMP: Inferred from mutant phenotype	21359875	GOA
involved in intracellular sodium ion homeostasis	IDA IDA: Inferred from direct assay	24840010	GOA
involved in positive regulation of calcineurin-NFAT signaling cascade	IDA IDA: Inferred from direct assay	22688515	GOA
involved in positive regulation of calcium:sodium antiporter activity	IMP IMP: Inferred from mutant phenotype	15105296	GOA
involved in positive regulation of cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	21359875	GOA
involved in positive regulation of the force of heart contraction	IMP IMP: Inferred from mutant phenotype	15105296	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22688515	GOA
involved in proton transmembrane transport	IDA IDA: Inferred from direct assay	24840010	GOA
involved in regulation of cardiac muscle contraction by calcium ion signaling	IMP IMP: Inferred from mutant phenotype	15105296	GOA
involved in regulation of intracellular pH	IDA IDA: Inferred from direct assay	15035633	GOA
involved in regulation of pH	IDA IDA: Inferred from direct assay	8901634	GOA
involved in regulation of the force of heart contraction by cardiac conduction	IMP IMP: Inferred from mutant phenotype	21359875	GOA
involved in response to acidic pH	IDA IDA: Inferred from direct assay	8901634	GOA
involved in response to muscle stretch	IMP IMP: Inferred from mutant phenotype	15105296	GOA
involved in sodium ion import across plasma membrane	IDA IDA: Inferred from direct assay	2536298	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of cation-transporting ATPase complex	IDA IDA: Inferred from direct assay	24840010	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21553168	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	22688515	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15035633	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC9A1 Protein Structure

b_cpa1

0
200
400
600
815 a.a.

Protein Preferred Names	Protein Names
sodium/hydrogen exchanger 1	Na(+)/H(+) exchanger 1

SLC9A1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC9A1	P19634	TESC	Homo sapiens	Q96BS2	MST	30287853
Intra	SLC9A1	P19634	TESC	Homo sapiens	Q96BS2	ITC	30287853
Intra	SLC9A1	P19634	TESC	Homo sapiens	Q96BS2	GMS	30287853

Cross: Cross-species interaction Intra: Intraspecies interaction

SLC9A1 Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P810784	SLC9A1 Antibody (YA10027)	WB	Human

Related Diseases

Diseases	Alias
Lichtenstein-Knorr Syndrome	Scar19 LIKNS Autosomal Recessive Spinocerebellar Ataxia 19 Spinocerebellar Ataxia, Autosomal Recessive 19 Progressive Autosomal Recessive Ataxia-Deafness Syndrome Progressive Autosomal Recessive Ataxia-Sensorineural Hearing Loss Syndrome Spinocerebellar Ataxia, Autosomal Recessive, 19
Myocardial Stunning
Metabolic Acidosis
Ischemia	Acute Coronary Syndrome
Christianson Syndrome	X-Linked Angelman-Like Syndrome X-Linked Intellectual Disability, South African Type X-Linked Intellectual Disability-Craniofacial Dysmorphism-Epilepsy-Ophthalmoplegia-Cerebellar Atrophy Syndrome Mental Retardation, Microcephaly, Epilepsy, And Ataxia Syndrome Mental Retardation, X-Linked Syndromic, Christianson Type Mrxsch Angelman-Like Syndrome X-Linked Intellectual Disability Microcephaly Epilepsy And Ataxia Syndrome Intellectual Disability X-Linked Syndromic Christianson Type Mrxs Christianson X-Linked Intellectual Disability - Craniofacial Dysmorphism - Epilepsy - Ophthalmoplegia - Cerebellar Atrophy Angelman-Like Syndrome, X-Linked Intellectual Deficit, X-Linked, South African Type Mental Retardation X-Linked, South African Type Mental Retardation, X-Linked, Syndromic, Christianson Type
Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 3	PEOA3 Autosomal Dominant Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions 3 Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant, 3 Chronic Progressive External Ophthalmoplegia Progressive External Ophthalmoplegia, Autosomal Dominant 3 Autosomal Dominant Progressive External Ophthalmoplegia 3 Cpeo Graefe Disease Mitochondrial Ocular Myopathy Ocular Myopathy Of Von Graefe-Fuchs Progressive External Ophthalmoplegia Autosomal Dominant 3 Progressive External Ophthalmoplegia, Autosomal Dominant, 3 Ophthalmoplegia, External, Progressive, With Mitochondrial Dna Deletions, Autosomal Dominant, Type 3 Kearns-Sayre Syndrome
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Gastroesophageal Reflux	Gastroesophageal Reflux Disease Gerd GER Gastroesophageal Reflux, Pediatric Acid Reflux Gastresophageal Reflux Gastro-Esophageal Reflux Gerd - Gastro-Esophageal Reflux Disease
Mitochondrial Complex Iii Deficiency, Nuclear Type 2	Mitochondrial Complex Iii Deficiency Nuclear Type 2 MC3DN2 Mitochondrial Complex Ii Deficiency, Nuclear Type 3 MC2DN3 Mitochondrial Complex 2 Deficiency, Nuclear Type 3 Mitochondrial Complex Iii Deficiency, Nuclear 2
Vas Deferens, Congenital Bilateral Aplasia Of	Congenital Bilateral Absence Of Vas Deferens CBAVD Cavd Congenital Bilateral Aplasia Of Vas Deferens Congenital Bilateral Absence Of The Vas Deferens Congenital Bilateral Agenesis Of Vas Deferens Absence Of Vas Deferens Absent Vasa Congenital Absence Of Vas Deferens Congenital Aplasia Of Vas Deferens Absent Vas Deferens Vas Deferens, Congenital Bilateral Absence
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Anomaly Coronary Artery Disease, Susceptibility To Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency
Ventricular Fibrillation, Paroxysmal Familial, 1	Paroxysmal Familial Ventricular Fibrillation Ivf Ventricular Fibrillation, Idiopathic Ventricular Fibrillation VF1 Vf Ventricular Fibrillation, Familial, 1 Paroxysmal Ventricular Fibrillation Idiopathic Ventricular Fibrillation Ventricular Fibrillation, Paroxysmal Familial, Type 1 Ventricular Fibrillation, Paroxysmal Familial Familial Paroxysmal Ventricular Fibrillation 1 Susceptibility To Ventricular Fibrillation During Myocardial Infarction Ventricular Fibrillation Adverse Event
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS13341	SLC9A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13349	SLC9B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19075	Slc9a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25566	Slc9a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLC9A1	VGNC	VGNC:53473
Macaca mulatta	SLC9A1	VGNC	VGNC:82241
Rattus norvegicus	SLC9A1	RGD	RGD:3718
Mus musculus	SLC9A1	MGD	MGI:102462
Felis catus	SLC9A1	VGNC	VGNC:80360
Others	SLC9A1	NCBI