A cytotoxic triterpene saponin from the root bark of Aralia dasyphylla

  • J Nat Prod. 1999 Jul;62(7):1030-2. doi: 10.1021/np9805185.
K Xiao  1 ,  Y H Yi ,  Z Z Wang ,  H F Tang ,  Y Q Li ,  H W Lin
Affiliations
  • 1. School of Pharmacy, Second Military Medical University, Shanghai 200433, People's Republic of China. [email protected]
PMID: 10425135 DOI: 10.1021/np9805185
Abstract

A novel triterpene saponin (1) was isolated from an ethanol extract of the root bark of Aralia dasyphylla. Its structure was elucidated as 3-O-[beta-D-glucopyranosyl (1-->3)-beta-D-galactopyranosyl(1-->2)]-beta-D-glucuronopyranosyl- ole anolic acid-28-O-beta-D-glucopyranoside, according to spectral and chemical evidence. Compound 1 showed significant cytotoxic activity against KB and Hela-S(3) cells.