2. Academic Validation
  3. LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription

LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription

  • Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16531-6. doi: 10.1073/pnas.0407123101.
Tyson V Sharp 1,  Fernando Munoz,  Dimitra Bourboulia,  Nadege Presneau,  Eva Darai,  Hsei-Wei Wang,  Mark Cannon,  David N Butcher,  Andrew G Nicholson,  George Klein,  Stephan Imreh,  Chris Boshoff
Affiliations

Affiliation

  • 1 Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, Cruciform Building, University College London, London WC1E 6BT, United Kingdom. [email protected]
PMID: 15542589 DOI: 10.1073/pnas.0407123101
Abstract

LIM domains-containing protein 1 (LIMD1) is encoded at chromosome 3p21.3, a region commonly deleted in many solid malignancies. However, the function of LIMD1 is unknown. Here we show that LIMD1 specifically interacts with retinoblastoma protein (pRB), inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. LIMD1 blocks tumor growth in vitro and in vivo and is down-regulated in the majority of human lung Cancer samples tested. Our data indicate that LIMD1 is a tumor-suppressor gene, the protein product of which functionally interacts with pRB and the loss of which promotes lung carcinogenesis.

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