Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands

  • Bioorg Med Chem Lett. 2006 Mar 1;16(5):1130-3. doi: 10.1016/j.bmcl.2005.11.095.
Raman K Bakshi  1 ,  Qingmei Hong ,  Rui Tang ,  Rubana N Kalyani ,  Tanya Macneil ,  David H Weinberg ,  Lex H T Van der Ploeg ,  Arthur A Patchett ,  Ravi P Nargund
Affiliations
  • 1. Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065-0900, USA. [email protected]
PMID: 16364639 DOI: 10.1016/j.bmcl.2005.11.095
Abstract

Design and synthesis of potent MC4 selective agonists based on cyclohexylpiperidine derived cyclic urea, oxazolidinones, and sulfonamide based privileged structures are disclosed.