Ginsenoside Rb1 Alleviated High-Fat-Diet-Induced Hepatocytic Apoptosis via Peroxisome Proliferator-Activated Receptor γ

  • Biomed Res Int. 2020 Jul 13;2020:2315230. doi: 10.1155/2020/2315230.
Bing Song  1 ,  Yao Sun  2 ,  Yafen Chu  3 ,  Jing Wang  1 ,  Hongwei Zheng  1 ,  Lili Liu  1 ,  Wang Cai  4 ,  Haoqiang Zhang  5
Affiliations
  • 1. Department of Endocrinology, First Affiliated Hospital of Jinzhou Medical University, China.
  • 2. Department of Pharmacy, Taikang Xianlin Drum Tower Hospital, Medical School of Nanjing University, China.
  • 3. Department of Endocrinology, Ningbo Medical Center Lihuili Hospital, China.
  • 4. Department of Obstetrics and Gynecology, First Affiliated Hospital of Jinzhou Medical University, China.
  • 5. Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, China.
PMID: 32733933 DOI: 10.1155/2020/2315230
Abstract

Objective: High-fat-diet- (HFD-) induced hepatic cell Apoptosis is common in mice with nonalcoholic fatty liver disease (NAFLD). We aim to investigate the effect of Ginsenoside Rb1 (GRb1) on hepatocyte Apoptosis.

Methods: C57BL/6J mice with HFD were used to induce a liver-injured model with cell Apoptosis. In addition, GRb1 was used to treat HFD-induced Apoptosis in a liver with or without inhibitor of Peroxisome Proliferator-activated Receptor γ (PPAR-γ).

Results: Compared with C57BL/6J mice with common chow, there are downregulated PPAR-γ but upregulated cell Apoptosis in the liver of mice with HFD. Furthermore, GRb1 elevated the hepatic PPAR-γ level and suppressed hepatocytic Apoptosis. However, GW9662 abolished the effects of GRb1 on Apoptosis in the liver.

Conclusions: GRb1 alleviated HFD-induced Apoptosis of hepatocytes of mice via PPAR-γ.

Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-16578
    GW9662
    99.98%, PPARγ Antagonist
    target: PPAR
    Research Areas: Cancer