Therapeutic Prospects of αv Integrins Inhibition in Fibrotic Lung Diseases and Carcinogenesis

  • Int J Mol Sci. 2025 Jun 27;26(13):6202. doi: 10.3390/ijms26136202.
Eugenija Leonidovna Golovina  1 ,  Veronika Vladimirovna Kochubey  1 ,  Marina Alekseevna Shabanova  1 ,  Darya Maksimovna Chekhvalova  1 ,  Valentina Alexandrovna Serebryakova  1 ,  Evgenii Germanovich Skurikhin  2 ,  Olga Evgenievna Vaizova  1 ,  Sergey Georgievich Morozov  2 ,  Aslan Amirkhanovich Kubatiev  2 ,  Alexander Mikhaylovich Dygai  2  3
Affiliations
  • 1. Department of Pharmacology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk 634050, Russia.
  • 2. Laboratory of Regulation of Reparative Processes, Institute of General Pathology and Pathophysiology, Moscow 125315, Russia.
  • 3. Laboratory of Regulation of Reparative Processes, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk 634050, Russia.
PMID: 40649983 DOI: 10.3390/ijms26136202
Abstract

The uncontrolled fibrosis of lung tissue can lead to premature death in patients suffering from idiopathic pulmonary fibrosis (IPF), and it complicates the course of chronic obstructive pulmonary disease (COPD) and emphysema. It is also a risk factor for developing lung Cancer. Antifibrotic drugs, such as nantedanib and pirfenidone, are able to slow down the progression of pulmonary fibrosis, but more effective treatment is still needed to reverse it. Studies on the pathogenesis of tissue fibrosis have demonstrated that integrins play a crucial role affecting the development of pulmonary fibrosis, for example, by activating transforming growth factor-β (TGF-β). Taking the above into consideration, targeting specific integrins could offer promising opportunities for managing fibroplastic changes in lung tissue. Integrins are a type of transmembrane molecule that mediate interactions between cells and extracellular matrix (ECM) molecules. This review discusses the role of integrins in the pathogeneses of respiratory diseases and carcinogenesis, as well as presents promising approaches to the drug therapy of pulmonary fibrosis of various etiologies based on Integrin inhibition.

Keywords
chronic obstructive pulmonary disease; idiopathic pulmonary fibrosis; lung cancer; αv integrin.
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