E2F6 - E2F transcription factor 6 Gene

Also Known as E2F-6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1876

About E2F6

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:11,444,375-11,466,161 (from NCBI)

This gene has 12 transcripts (splice variants), 245 orthologues and 7 paralogues. Ubiquitous expression in testis (RPKM 4.1), endometrium (RPKM 3.9) and 25 other tissues.

Summary

This gene encodes a member of a family of transcription factors that play a crucial role in the control of the cell cycle. The protein encoded by this gene lacks the transactivation and tumor suppressor protein association domains found in Other family members, and contains a modular suppression domain that functions in the inhibition of transcription. It interacts in a complex with chromatin modifying factors. There are pseudogenes for this gene on chromosomes 22 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

E2F6 Products (6)

mRNA Protein Name
NM_001278275.2 NP_001265204.1 transcription factor E2F6 isoform 2
NM_001278276.2 NP_001265205.1 transcription factor E2F6 isoform 3
NM_001278277.2 NP_001265206.1 transcription factor E2F6 isoform 3
NM_001278278.2 NP_001265207.1 transcription factor E2F6 isoform 3
NM_198256.4 NP_937987.2 transcription factor E2F6 isoform 1
NM_212540.3 NP_997705.1 transcription factor E2F6 isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
9501179 GOA
contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
9501179 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9501179 GOA
Cellular Component GO Annotation Evidence References Source
part of MLL1 complex IDA
IDA: Inferred from direct assay
15960975 GOA
part of RNA polymerase II transcription regulator complex IDA
IDA: Inferred from direct assay
9501179 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17001316 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

E2F6 Protein Structure

E2F_TDP

E2F_TDP: E2F/DP family winged-helix DNA-binding domain (63 - 128)

  • 0
  • 100
  • 200
  • 281 a.a.
Protein Preferred Names Protein Names

transcription factor E2F6

E2F6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
E2F6 O75461 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
25416956
Intra
E2F6 O75461 TFDP2 Homo sapiens Q14188-5
Validated Y2H
26871637
Intra
E2F6 O75461 TFDP2 Homo sapiens Q14188-5
Validated Y2H
32296183
Intra
E2F6 O75461 TFDP2 Homo sapiens Q14188-5
Y2H Prey Pooling
26871637
Intra
E2F6 O75461 TFDP2 Homo sapiens Q14188-5
Y2H Array
26871637
Intra
E2F6 O75461 TFDP1 Homo sapiens Q14186
Validated Y2H
32296183
Intra
E2F6 O75461 TFDP1 Homo sapiens Q14186
Y2H Array
25416956
Intra
E2F6 O75461 TFDP1 Homo sapiens Q14186
Y2H Prey Pooling
26871637
Intra
E2F6 O75461 TFDP1 Homo sapiens Q14186
Y2H Array
20211142
Intra
E2F6 O75461 TFDP1 Homo sapiens Q14186
Y2H Prey Pooling
32296183
Intra
E2F6 O75461 TFDP1 Homo sapiens Q14186
Y2H Array
32296183
Intra
E2F6 O75461 TFDP1 Homo sapiens Q14186
Y2H Pooling
16189514
Intra
E2F6 O75461 TFDP1 Homo sapiens Q14186
TAP
27705803
Intra
E2F6 O75461 TFDP1 Homo sapiens Q14186
Anti Tag CoIP
33961781
Intra
E2F6 O75461 TFDP1 Homo sapiens Q14186
Validated Y2H
26871637
Intra
E2F6 O75461 TFDP1 Homo sapiens Q14186
Anti Tag CoIP
28514442
Intra
E2F6 O75461 TFDP1 Homo sapiens Q14186
Y2H Array
26871637
Intra
E2F6 O75461 MAX Homo sapiens P61244
TAP
27705803
Intra
E2F6 O75461 MAX Homo sapiens P61244
TAP
25609649
Intra
E2F6 O75461 TFDP2 Homo sapiens Q14188
Y2H Array
25416956
Intra
E2F6 O75461 TFDP2 Homo sapiens Q14188
Y2H Pooling
16189514
Intra
E2F6 O75461 TFDP2 Homo sapiens Q14188
Anti Tag CoIP
33961781
Intra
E2F6 O75461 TFDP2 Homo sapiens Q14188
TAP
27705803
Intra
E2F6 O75461 TFDP2 Homo sapiens Q14188
Anti Tag CoIP
28514442
Intra
E2F6 O75461 TFDP2 Homo sapiens Q14188
MAPPIT
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

E2F6 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82026 E2F6 Antibody (YA1771) WB, ICC/IF, FC Human

Related Diseases

Diseases Alias
Retinal Cancer

  • Malignant Neoplasm Of Retina

  • Retinal Neoplasms

  • Malignant Retinal Neoplasm

  • Malignant Tumor Of Retina

  • Neoplasm Of Retina

  • Retinal Tumor

  • Retinal Neoplasm

  • Cancer Of The Retina

  • Malignant Retinal Tumour

  • Malignant Tumour Of Retina

  • Primary Malignant Neoplasm Of Retina
Bilateral Retinoblastoma
Soft Palate Cancer

  • Malignant Tumor Of Soft Palate

  • Malignant Tumor Of The Soft Palate

  • Palate Cancer Soft Palate
Familial Retinoblastoma

  • Hereditary Retinoblastoma

  • Retinoblastoma
Ocular Cancer

  • Eye Neoplasm

  • Eye Carcinoma

  • Eye Cancer

  • Eye Neoplasms

  • Malignant Eye Neoplasm

  • Neoplasm Of Eye

  • Neoplasm Of Eye Proper

  • Ocular Tumor

  • Carcinoma Of Eye

  • Ocular Carcinoma

  • Malignant Tumor Of Eye
Retinal Disease

  • Retinal Diseases

  • Retinal Disorder

  • Retinal Disorders
Eye Disease

  • Eye Diseases

  • Abnormality Of The Eye

  • Toxoplasma Oculopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04115 E2F6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20270 E2f6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26778 E2f6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta E2F6 VGNC VGNC:72027
Mus musculus E2F6 MGD MGI:1354159
Felis catus E2F6 VGNC VGNC:61697
Canis familiaris E2F6 VGNC VGNC:40168
Rattus norvegicus E2F6 RGD RGD:631412
Bos taurus E2F6 VGNC VGNC:28290
Others E2F6 NCBI