E2F6 - E2F transcription factor 6 Gene

Homo sapiens

Also known as E2F-6

Gene ID: 1876 | Gene type: protein coding

About E2F6

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:11,444,375-11,466,161 (from NCBI)

This gene has 12 transcripts (splice variants), 245 orthologues and 7 paralogues. Ubiquitous expression in testis (RPKM 4.1), endometrium (RPKM 3.9) and 25 other tissues.

Summary

This gene encodes a member of a family of transcription factors that play a crucial role in the control of the cell cycle. The protein encoded by this gene lacks the transactivation and tumor suppressor protein association domains found in other family members, and contains a modular suppression domain that functions in the inhibition of transcription. It interacts in a complex with chromatin modifying factors. There are pseudogenes for this gene on chromosomes 22 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

E2F6 Products(6)

mRNA	Protein	Name
NM_001278275.2	NP_001265204.1	transcription factor E2F6 isoform 2
NM_001278276.2	NP_001265205.1	transcription factor E2F6 isoform 3
NM_001278277.2	NP_001265206.1	transcription factor E2F6 isoform 3
NM_001278278.2	NP_001265207.1	transcription factor E2F6 isoform 3
NM_198256.4	NP_937987.2	transcription factor E2F6 isoform 1
NM_212540.3	NP_997705.1	transcription factor E2F6 isoform 4

E2F6 Protein Structure

E2F_TDP

0
100
200
281 a.a.

Protein Preferred Names

Protein Names

transcription factor E2F6

Related Diseases

Diseases

Alias

Retinal Cancer

Malignant Neoplasm Of Retina	Retinal Neoplasms
Malignant Retinal Neoplasm	Malignant Tumor Of Retina
Neoplasm Of Retina	Retinal Tumor
Retinal Neoplasm	Cancer Of The Retina
Malignant Retinal Tumour	Malignant Tumour Of Retina
Primary Malignant Neoplasm Of Retina

Bilateral Retinoblastoma

Soft Palate Cancer

Malignant Tumor Of Soft Palate	Malignant Tumor Of The Soft Palate
Palate Cancer Soft Palate

Familial Retinoblastoma

Hereditary Retinoblastoma

Retinoblastoma

Ocular Cancer

Eye Neoplasm	Eye Carcinoma
Eye Cancer	Eye Neoplasms
Malignant Eye Neoplasm	Neoplasm Of Eye
Neoplasm Of Eye Proper	Ocular Tumor
Carcinoma Of Eye	Ocular Carcinoma
Malignant Tumor Of Eye

Retinal Disease

Retinal Diseases	Retinal Disorder
Retinal Disorders

Eye Disease

Eye Diseases	Abnormality Of The Eye
Toxoplasma Oculopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04115	E2F6 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	E2F6	VGNC	VGNC:72027
Mus musculus	E2F6	MGD	MGI:1354159
Felis catus	E2F6	VGNC	VGNC:61697
Canis familiaris	E2F6	VGNC	VGNC:40168
Rattus norvegicus	E2F6	RGD	RGD:631412
Bos taurus	E2F6	VGNC	VGNC:28290