Grk3 - G protein-coupled receptor kinase 3 Gene

Also Known as Adrbk2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25372

Summary

Enables D1 Dopamine Receptor binding activity; G protein-coupled receptor kinase activity; and beta-adrenergic receptor kinase activity. Involved in several processes, including cellular protein metabolic process; desensitization of G protein-coupled receptor signaling pathway; and response to morphine. Located in several cellular components, including Z disc; dendrite; and sperm midpiece. Biomarker of Parkinson's disease; hypertension; and hypothyroidism. Orthologous to human GRK3 (G protein-coupled receptor kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Grk3 Products (1)

mRNA Protein Name
NM_012897.3 NP_037029.2 beta-adrenergic receptor kinase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables D1 dopamine receptor binding IPI
IPI: Inferred from physical interaction
20837135 RGD
enables G protein-coupled receptor kinase activity IDA
IDA: Inferred from direct assay
1403099 RGD
enables beta-adrenergic receptor kinase activity IDA
IDA: Inferred from direct assay
1403099 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IEP
IEP: Inferred from expression pattern
29081032 RGD
involved in desensitization of G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
20837135 RGD
involved in desensitization of G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
8381966 RGD
involved in inositol phosphate metabolic process IMP
IMP: Inferred from mutant phenotype
17573483 RGD
involved in intracellular protein transport IMP
IMP: Inferred from mutant phenotype
8276821 RGD
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
20837135 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
1403099 RGD
involved in protein phosphorylation IMP
IMP: Inferred from mutant phenotype
8381966 RGD
involved in rhodopsin metabolic process IMP
IMP: Inferred from mutant phenotype
17573483 RGD
Cellular Component GO Annotation Evidence References Source
located in Z disc IDA
IDA: Inferred from direct assay
15584034 RGD
located in axon IDA
IDA: Inferred from direct assay
1403099 RGD
located in dendrite terminus IDA
IDA: Inferred from direct assay
16374707 RGD
located in dendritic shaft IDA
IDA: Inferred from direct assay
1403099 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
1403099 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
1403099 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
20837135 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
1403099 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
1403099 RGD
located in sperm midpiece IDA
IDA: Inferred from direct assay
8529092 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beta-adrenergic receptor kinase 2

  • adrenergic receptor kinase, beta 2 (G-protein-linked receptor kinase)

  • adrenergic, beta, receptor kinase 2

  • beta ARK2

  • beta-ARK-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103045A CMPD101 hydrochloride Inhibitor / Unkown
HY-RS05814 GRK3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20749 Grk3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27261 Grk3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grk3 NCBI NCBI:157