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Cat. No.: HY-103045A

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CMPD101 hydrochloride

4 Cited Publications

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Based on 4 publication(s) in Google Scholar

CMPD101 hydrochloride is a novel membrane-permeable, small-molecule inhibitor of both GRK2 and GRK3 with IC₅₀s of 18 nM and 5.4 nM, respectively. CMPD101 hydrochloride also inhibits Rho-associated kinase 2 (ROCK-2) and PKCα (IC₅₀s =1.4 μM and 8.1 μM, respectively).

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CAS No.: 1941168-71-3
Formule: C₂₄H₂₂ClF₃N₆O
Masse moléculaire:502.92

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

CMPD101 hydrochloride Chemical Structure

CAS No.: 1941168-71-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Publications (4)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

GRK2

PKCα

8.1 μM (IC₅₀)

ROCK2

1.4 μM (IC₅₀)

Voir tous les produits spécifiques à Isoform PKC :

Voir tous les produits spécifiques à Isoform ROCK :

Chemical Information

CAS No. 1941168-71-3
Masse moléculaire 502.92
Formule C₂₄H₂₂ClF₃N₆O
SMILES

O=C(C1=CC(NCC2=NN=C(C3=CC=NC=C3)N2C)=CC=C1)NCC4=CC=CC=C4C(F)(F)F.[H]Cl
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (4)

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J Exp Clin Cancer Res

2,6-DMBQ is a novel mTOR inhibitor that reduces gastric cancer growth in vitro and in vivo. [Abstract]

2020 Jun 9;39(1):107. PMID: 32517736

CMPD101 hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2020 Jun 9;39(1):107. [Abstract]

CMPD101 (0.1-30 μM) significantly reduced growth of gastric cancer cells.
Int J Mol Sci

Cellular Electrical Impedance as a Method to Decipher CCR7 Signalling and Biased Agonism. [Abstract]

2022 Aug 10;23(16):8903. PMID: 36012168

CMPD101 hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Aug 10;23(16):8903. [Abstract]

CMPD101 (10 µM) significantly increased the maximal CI_[3-20] and AUC_[20-120].
Biomolecules

Ketamine Improves Desensitization of µ-Opioid Receptors Induced by Repeated Treatment with Fentanyl but Not with Morphine. [Abstract]

2022 Mar 10;12(3):426. PMID: 35327617

CMPD101 hydrochloride purchased from MedChemExpress. Usage Cited in: Biomolecules. 2022 Mar 10;12(3):426. [Abstract]

CMPD101 (0.001–10 μM) significantly cancelled the ketamine-induced improvement of the decrease in MOR activity in HEK293 cells evoked by repeated administration of 100 nM fentanyl.

CMPD101 hydrochloride purchased from MedChemExpress. Usage Cited in: Biomolecules. 2022 Mar 10;12(3):426. [Abstract]

CMPD101 (1-10 µM) significantly cancelled the ketamine-induced improvement in the rescue of cAMP in HEK293 cells caused by repeated administration of 100 nM fentanyl.

CMPD101 hydrochloride purchased from MedChemExpress. Usage Cited in: Biomolecules. 2022 Mar 10;12(3):426. [Abstract]

CMPD101 (1–10 µM) significantly cancelled the ketamine-induced enhancement of β-arrestin recruitment to MOR U2OS OPRM1 induced by the repeated administration of 100 nM fentanyl.
ACS Omega

Determination of Site-Specific Phosphorylation Occupancy Using Targeted Mass Spectrometry Reveals the Regulation of Human Apical Bile Acid Transporter, ASBT. [Abstract]

2024 Aug 30;9(37):38477-38489. PMID: 39310206

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Okawa T, et al. Design, Synthesis, and Evaluation of the Highly Selective and Potent G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure. J Med Chem. 2017 Aug 24;60(16):6942-6990. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

CMPD101 hydrochloride

4 Cited Publications

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Publications (4)
Pureté et documentation
Références

1/16
1/16

CMPD101 hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Aug 10;23(16):8903. [Abstract]

Customer Validation
CMPD101 (10 µM) significantly increased the maximal CI_[3-20] and AUC_[20-120].
1/16

CMPD101 hydrochloride purchased from MedChemExpress. Usage Cited in: Biomolecules. 2022 Mar 10;12(3):426. [Abstract]

Customer Validation
CMPD101 (0.001–10 μM) significantly cancelled the ketamine-induced improvement of the decrease in MOR activity in HEK293 cells evoked by repeated administration of 100 nM fentanyl.
1/16

CMPD101 hydrochloride purchased from MedChemExpress. Usage Cited in: Biomolecules. 2022 Mar 10;12(3):426. [Abstract]

Customer Validation
CMPD101 (1-10 µM) significantly cancelled the ketamine-induced improvement in the rescue of cAMP in HEK293 cells caused by repeated administration of 100 nM fentanyl.
1/16

CMPD101 hydrochloride purchased from MedChemExpress. Usage Cited in: Biomolecules. 2022 Mar 10;12(3):426. [Abstract]

Customer Validation
CMPD101 (1–10 µM) significantly cancelled the ketamine-induced enhancement of β-arrestin recruitment to MOR U2OS OPRM1 induced by the repeated administration of 100 nM fentanyl.
1/16

CMPD101 hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2020 Jun 9;39(1):107. [Abstract]

Customer Validation
CMPD101 (0.1-30 μM) significantly reduced growth of gastric cancer cells.

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CMPD101 hydrochloride

Publications Citing Use of MedChemExpress (MCE) CMPD101 hydrochloride

Voir tous les produits spécifiques à Isoform PKC

Voir tous les produits spécifiques à Isoform ROCK

Activité biologique

Chemical Information

Publications (4)

Pureté et documentation

Références

Calculators

Help & FAQs

CMPD101 hydrochloride Related Classifications

HY-103045A Related Classifications