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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
AXIN1
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "AXIN1" in MCE Product Catalog:
Synonyms: STP1002
Basroparib (STP1002) is a selective, orally active inhibitor of tankyrase (TNKS1/TNKS2) with IC50 of 29.94 nM and 3.68 nM for TNKS1 and TNKS2, respectively. Basroparib has an IC50 of >10 μM for PARP1. Basroparib binds to TNKS, stabilizes AXIN1/2 proteins, blocks Wnt/β-catenin signaling pathway, inhibits tumor cell proliferation and induces apoptosis, while reducing cancer stem cell properties. Basroparib can be used in colorectal cancer (CRC) studies with KRAS mutations (such as G12V/G12D) to overcome acquired resistance to MEK inhibitors. STP1002 has synergistic antitumor activity with MEK inhibitors [1] .
Cat. No.: HY-RS22402
Target:
연구분야:
Axin1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Axin1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS01291
Target:
연구분야:
AXIN1 Human Pre-designed siRNA Set A contains three designed siRNAs for AXIN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS28926
Target:
연구분야:
Axin1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Axin1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
YW2065 is an Axin-1 stabilizer. Axin-1 is a scaffolding protein that regulates proteasome degradation of β-catenin. YW2065 exhibits anti-colorectal cancer effects via dual activities of wnt/β-catenin signaling inhibition and AMPK activation [1].
Cat. No.: HY-173349
CAS No.: 3120102-92-0
TDI-012804 is a TNKS2 inhibitor that selectively inhibits intracellular endogenous TNKS2 protein. TDI-012804 increases the expression of AXIN1 protein in cells that are heterozygous (Tnks1HET) and completely knocks out (Tnks1KO) for TNKS1. TDI-012804 inhibits the proliferation of ApcQ1405X/Tnks1KO organoids (EC50 of 59.1 nM) and is selectively toxic to Tnks1KO AKP-G12D and AKP-G13D organoids [1].
Cat. No.: HY-P810034
Synonyms: AXUD1, TAIP3, CSRNP1, Cysteine/serine-rich nuclear protein 1, CSRNP-1, AXIN-1 up-regulated gene 1 protein, Protein URAX1, TGF-beta-induced apoptosis protein 3, TAIP-3
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
