3120102-92-0
3120102-92-0
Chemical Structure
TDI-012804
- CAS No.: 3120102-92-0
- Formula:C30H26N4O4
- Molecular Weight:506.55
InChIKey: KVOHBVVFLUPAFE-UHFFFAOYSA-N
SMILES: COC1=C(C(NC2=CC=C(C(NC(C3=CC=C(C(O)(C)C)C=C3)=N4)=O)C4=C2)=O)C=NC(C5=CC=CC=C5)=C1
Biological Activity: TDI-012804 is a TNKS2 inhibitor that inhibits the PARP catalytic domain activity of TNKS1/TNKS2. TDI-012804 stabilizes AXIN1 and inhibits WNT signaling. TDI-012804 reduces colony formation and proliferation of TNKS1-deficient cancer cell lines and APC-mutant intestinal organoids, whereas TNKS1 wild-type organoids show lower sensitivity. TDI-012804 can be used in research related to colorectal cancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TDI-012804 | 99.53% | TDI-012804 is a TNKS2 inhibitor that inhibits the PARP catalytic domain activity of TNKS1/TNKS2. TDI-012804 stabilizes AXIN1 and inhibits WNT signaling. TDI-012804 reduces colony formation and proliferation of TNKS1-deficient cancer cell lines and APC-mutant intestinal organoids, whereas TNKS1 wild-type organoids show lower sensitivity. TDI-012804 can be used in research related to colorectal cancer. | ||||||||||||||||||||
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