2 Results for "

N-803

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "N-803" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-P99661
CAS No.: 2135939-52-3

Target:  

Interleukin Related

Research Areas:  

Cancer

Inbakicept is a dimeric human IL-15 receptor alpha (IL-15 Ra) sushi domain/human IgG1 Fc fusion protein and is an IL-15 superagonist complex. Inbakicept is able to form complex N-803 (Nogapendekin alfa inbakicept) with the IL-15 antibody Nogapendekin alfa in a 1:2 ratio. N-803 mimics the function of IL-15 and amplifies anti-CD20 mAb-mediated NK cell responses and antibody-dependent cellular cytotoxicity (ADCC). N-803 also increases degranulation and IFNγ production in cells .
Cat. No.: HY-P99759
CAS No.: 1622189-43-8
Synonyms: IL-15N72D

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology Cancer

Nogapendekin alfa (his tag), a soluble protein subunit of a human interleukin (IL)-15 variant, is a superagonist of IL-15. Nogapendekin alfa (his tag) promotes the proliferation and viability of immune cells. Nogapendekin alfa (his tag) combines with Inbakicept (HY-P99661) at a ratio of 2:1, to form N-803 (Nogapendekin alfa inbakicept), an IL-15 cytokine antibody fusion protein. N-803 reduces tumor burden by activation of NK cells and CD8 + T cells .