3 Results for "

rapalink

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "rapalink" in MCE Product Catalog:

14
RapaLink-1
RapaLink-1
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14 Cited Publications
製品番号: HY-111373
CAS 番号: 1887095-82-0
純度:  99.92%
Target:  

mTOR Autophagy

研究分野:  

Cancer

RapaLink-1, the third-generation bivalent mTOR inhibitor, combines Rapamycin (HY-10219) with MLN0128 (HY-13328, a second-generation mTOR kinase inhibitor) by an inert chemical linker. RapaLink-1 shows better efficacy than Rapamycin or mTOR kinase inhibitors (TORKi), potently blocking cancer-derived, activating mutants of mTOR. RapaLink-1 can cross the blood-brain barrier. RapaLink-1 binding to FKBP12 results in targeted and durable inhibition of mTORC1. RapaLink-1 plays an antithrombotic role in antiphospholipid syndrome by improving autophagy. Anticancer activity .
Demethyl-sapanisertib-C2-amide-PEG7-C2-N3
Demethyl-sapanisertib-C2-amide-PEG7-C2-N3
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製品番号: HY-176947
CAS 番号: 1887095-85-3
Target:  

Drug Intermediate

研究分野:  

Cancer

Demethyl-sapanisertib-C2-amide-PEG7-C2-N3 (Compound 10c) is an azide group linker used for coupling, which can be employed in the synthesis of "Rapa-Link" compounds, such as M-1111 (HY-176948), an mTOR inhibitor .
M-1111
M-1111
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製品番号: HY-176948
CAS 番号: 1887095-86-4
Target:  

mTOR

研究分野:  

Cancer

M-1111 is a Rapa-Link inhibitor. M-1111 is covalently linked by Rapamycin (HY-10219) and an inhibitor of the active site mTOR. M-1111 has strong inhibitory activity on the mTORC1 signaling pathway (pS6 and p4E-BP1). M-1111 has nanomolar-level inhibitory activity against various cancer cells. M-1111 completely inhibits p4E-BP1 without inhibiting pAkt S473. M-1111 can be used for research on liver cancer, kidney cancer, and colorectal cancer .
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