1887095-86-4
Chemical Structure
M-1111
- CAS No.: 1887095-86-4
- Formula:C89H134N12O23
- Molecular Weight:1740.08
InChIKey: SZQPSJWHQXZGGL-GKFKMLLASA-N
SMILES: O=C([C@@]1(O)[C@@H](CC[C@@H](C[C@@H](/C(C)=C/C=C/C=C/[C@H](C[C@@H](C)C([C@@H]([C@@H](/C(C)=C/[C@H]2C)O)OC)=O)C)OC)O1)C)C(N3CCCC[C@H]3C(O[C@@H](CC2=O)[C@@H](C[C@H]4C[C@H]([C@H](OCCOCC5=CN(CCOCCOCCOCCOCCOCCOCCOCCNC(CCCCN6C7=C(C(N)=NC=N7)C(C8=CC(N=C(N)O9)=C9C=C8)=N6)=O)N=N5)CC4)OC)C)=O)=O
Biological Activity: M-1111 is a Rapa-Link inhibitor. M-1111 is covalently linked by Rapamycin (HY-10219) and an inhibitor of the active site mTOR. M-1111 has strong inhibitory activity on the mTORC1 signaling pathway (pS6 and p4E-BP1). M-1111 has nanomolar-level inhibitory activity against various cancer cells. M-1111 completely inhibits p4E-BP1 without inhibiting pAkt S473. M-1111 can be used for research on liver cancer, kidney cancer, and colorectal cancer[1].
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M-1111 | M-1111 is a Rapa-Link inhibitor. M-1111 is covalently linked by Rapamycin (HY-10219) and an inhibitor of the active site mTOR. M-1111 has strong inhibitory activity on the mTORC1 signaling pathway (pS6 and p4E-BP1). M-1111 has nanomolar-level inhibitory activity against various cancer cells. M-1111 completely inhibits p4E-BP1 without inhibiting pAkt S473. M-1111 can be used for research on liver cancer, kidney cancer, and colorectal cancer. | |||||||||||||||||||||
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Keywords
