Oprm1 - opioid receptor, mu 1 Gene

Also Known as mor; Oprm; muOR; MOP-R; MOR-1; M-OR-1; MOR-1O

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18390

Summary

This gene encodes the mu Opioid Receptor which is where drugs such as morphine and Other opioids have pharmacological effects. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

Oprm1 Products (10)

mRNA Protein Name
NM_001039652.2 NP_001034741.1 mu-type opioid receptor isoform MOR-1C
NM_001302793.1 NP_001289722.1 mu-type opioid receptor isoform MOR-1
NM_001302794.1 NP_001289723.1 mu-type opioid receptor isoform MOR-1G
NM_001302795.1 NP_001289724.1 mu-type opioid receptor isoform MOR-1M
NM_001302796.1 NP_001289725.1 mu-type opioid receptor isoform MOR-1N
NM_001304937.1 NP_001291866.1 mu-type opioid receptor isoform MOR-1A
NM_001304938.1 NP_001291867.1 mu-type opioid receptor isoform MOR-1B1
NM_001304948.1 NP_001291877.1 mu-type opioid receptor isoform MOR-1B2
NM_001304950.1 NP_001291879.1 mu-type opioid receptor isoform MOR-1D
NM_001304955.1 NP_001291884.1 mu-type opioid receptor isoform MOR-1U

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled opioid receptor activity IDA
IDA: Inferred from direct assay
8738226 MGI
enables G protein-coupled opioid receptor activity IGI
IGI: Inferred from genetic interaction
6933569 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18599439 MGI
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled opioid receptor signaling pathway IGI
IGI: Inferred from genetic interaction
6933569 MGI
acts upstream of or within adenylate cyclase-activating dopamine receptor signaling pathway IDA
IDA: Inferred from direct assay
8738226 MGI
acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
8738226 MGI
acts upstream of or within locomotory behavior IGI
IGI: Inferred from genetic interaction
12574430 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
10835636 MGI
involved in positive regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
16682964 MGI
involved in presynaptic modulation of chemical synaptic transmission EXP
EXP: Inferred from Experiment
31818459 MGI
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
31818459 MGI
involved in presynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
31818459 MGI
involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
9037090 MGI
involved in transmission of nerve impulse IMP
IMP: Inferred from mutant phenotype
6933569 MGI
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse EXP
EXP: Inferred from Experiment
31818459 MGI
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
31818459 MGI
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
31818459 MGI
located in membrane IDA
IDA: Inferred from direct assay
8738226 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mu-type opioid receptor

  • MOP receptor

  • mu opioid receptor MOR-1BI

  • mu opioid receptor MOR-1P

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-116163 ML350 / Unkown
HY-13906 Largazole Inhibitor / Unkown
HY-RS09806 OPRM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Oprm1 NCBI NCBI:4988