2093388-45-3
2093388-45-3
Chemical Structure
Lenalidomide-C5-NH2
- CAS No.: 2093388-45-3
- Formula:C18H23N3O3
- Molecular Weight:329.39
IUPAC Name: 3-(4-(5-aminopentyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
InChIKey: ZZXXBKHLDNFHCQ-UHFFFAOYSA-N
SMILES: O=C1NC(C(CC1)N2C(C3=CC=CC(CCCCCN)=C3C2)=O)=O
Biological Activity: Lenalidomide-C5-NH2 is an E3 ligase ligand-linker conjugate. Lenalidomide-C5-NH2 can be coupled to a target protein ligand via a linker to form a PROTAC molecule—such as a PROTAC degrader for MDM2[1][2].
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Lenalidomide-C5-NH2 | Lenalidomide-C5-NH2 is an E3 ligase ligand-linker conjugate. Lenalidomide-C5-NH2 can be coupled to a target protein ligand via a linker to form a PROTAC molecule—such as a PROTAC degrader for MDM2. | |||||||||||||||||||||
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References
- [1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481. [Content Brief]
- [2]. Yangbing Li, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019 Jan 24;62(2):448-466. [Content Brief]
Keywords
