3099809-16-9
Chemical Structure
AKT-IN-28
- CAS No.: 3099809-16-9
- Formula:C32H28FNO8
- Molecular Weight:573.57
InChIKey: ZSTYTPXENIMUGO-UHFFFAOYSA-N
SMILES: O=C1C2=C(O)C=CC(O)=C2C(C=C1[C@@H](C/C=C(C)\C)OC(CC3=CC=C(C=C3)NC(COC4=CC=C(C=C4)F)=O)=O)=O
Biological Activity: AKT-IN-28 is an Akt allosteric inhibitor, a derivative of Shikonin (HY-N0822). AKT-IN-28 effectively binds to the allosteric site of Akt through hydrophobic and hydrogen interactions with Kd of 2.07 μM. AKT-IN-28 significantly inhibits Akt activity, induces cell apoptosis, arrests cell cycle in G2/M phase, and suppresses proliferation, migration and metabolism of KRAS mutant colorectal cancer cells[1].
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AKT-IN-28 | AKT-IN-28 is an Akt allosteric inhibitor, a derivative of Shikonin (HY-N0822). AKT-IN-28 effectively binds to the allosteric site of Akt through hydrophobic and hydrogen interactions with Kd of 2.07 μM. AKT-IN-28 significantly inhibits Akt activity, induces cell apoptosis, arrests cell cycle in G2/M phase, and suppresses proliferation, migration and metabolism of KRAS mutant colorectal cancer cells. | |||||||||||||||||||||
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Keywords
