RBM7 - RNA binding motif protein 7 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10179

About RBM7

Cytogenetic location: 11q23.2 Genomic coordinates (GRCh38): 11:114,400,666-114,410,607 (from NCBI)

This gene has 8 transcripts (splice variants), 212 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 12.9), urinary bladder (RPKM 8.3) and 25 other tissues.

Summary

Enables 14-3-3 protein binding activity; pre-mRNA intronic binding activity; and snRNA binding activity. Involved in snRNA catabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RBM7 Products (5)

mRNA	Protein	Name
NM_001286045.2	NP_001272974.1	RNA-binding protein 7 isoform a
NM_001286046.2	NP_001272975.1	RNA-binding protein 7 isoform c
NM_001286047.2	NP_001272976.1	RNA-binding protein 7 isoform c
NM_001286048.2	NP_001272977.1	RNA-binding protein 7 isoform c
NM_016090.4	NP_057174.1	RNA-binding protein 7 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 14-3-3 protein binding	IDA IDA: Inferred from direct assay	25189701	GOA
enables 14-3-3 protein binding	IPI IPI: Inferred from physical interaction	25189701	GOA
enables RNA binding	IDA IDA: Inferred from direct assay	25578728	GOA
enables RNA binding	IMP IMP: Inferred from mutant phenotype	25189701	GOA
enables pre-mRNA intronic binding	IDA IDA: Inferred from direct assay	25578728	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16263084	GOA
enables snRNA binding	IDA IDA: Inferred from direct assay	25852104	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in snRNA catabolic process	IMP IMP: Inferred from mutant phenotype	25852104	GOA

Cellular Component GO Annotation	Evidence	References	Source
NOT located in nucleolus	IDA IDA: Inferred from direct assay	21855801	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	16263084	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21855801	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBM7 Protein Structure

RRM_1

0
100
200
266 a.a.

Protein Preferred Names	Protein Names
RNA-binding protein 7

RBM7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RBM7	Q9Y580	ZCCHC8	Homo sapiens	Q6NZY4	Pull Down	27905398
Intra	RBM7	Q9Y580	ZCCHC8	Homo sapiens	Q6NZY4	Anti Tag CoIP	26496610
Intra	RBM7	Q9Y580	ZCCHC8	Homo sapiens	Q6NZY4	Anti Tag CoIP	33961781
Intra	RBM7	Q9Y580	ZCCHC8	Homo sapiens	Q6NZY4	Anti Tag CoIP	28514442
Intra	RBM7	Q9Y580	CCDC88B	Homo sapiens	A6NC98	Y2H Array	32296183
Intra	RBM7	Q9Y580	CCDC88B	Homo sapiens	A6NC98	Y2H Prey Pooling	32296183
Intra	RBM7	Q9Y580	SF3B2	Homo sapiens	Q13435	Pull Down	27905398
Intra	RBM7	Q9Y580	SF3B2	Homo sapiens	Q13435	Anti Tag CoIP	33961781
Intra	RBM7	Q9Y580	SF3B2	Homo sapiens	Q13435	Anti Tag CoIP	28514442
Intra	RBM7	Q9Y580	EVI5L	Homo sapiens	Q96CN4	Y2H Prey Pooling	32296183
Intra	RBM7	Q9Y580	EVI5L	Homo sapiens	Q96CN4	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Trichohepatoenteric Syndrome 1	Trichohepatoenteric Syndrome Syndromic Diarrhea Tricho-Hepato-Enteric Syndrome Sd/The Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome THES1 Phenotypic Diarrhea Thes Phenotypic Diarrhea Of Infancy Diarrhea, Syndromic Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa Intractable Diarrhea With Phenotypic Anomalies Syndromatic Diarrhea Fatal Infantile Diarrhea With Trichorrhexis Nodosa
Trichohepatoenteric Syndrome 2	THES2
Pontocerebellar Hypoplasia, Type 1d	PCH1D Pontocerebellar Hypoplasia Type 1d Pontocerebellar Hypoplasia 1d Doid:0112323 Hypoplasia, Pontocerebellar, Type 1d
Pontocerebellar Hypoplasia, Type 1c	PCH1C Hypomyelination With Spinal Muscular Atrophy And Cerebellar Hypoplasia Pontocerebellar Hypoplasia Type 1c Pontocerebellar Hypoplasia 1c Doid:0112334 Hypoplasia, Pontocerebellar, Type 1c
Pontocerebellar Hypoplasia, Type 1e	Pontocerebellar Hypoplasia Type 1 PCH1E Norman Disease Pch1 Pontocerebellar Hypoplasia With Anterior Horn Cell Disease Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy Pontocerebellar Hypoplasia Type 1e Pontocerebellar Hypoplasia 1e Doid:0112322 Doid:0112330
Pontocerebellar Hypoplasia	Pch Congenital Pontocerebellar Hypoplasia Opch Hypoplasia, Pontocerebellar Pontoneocerebellar Hypoplasia Nonsyndromic Pontocerebellar Hypoplasia
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11758	RBM7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22295	Rbm7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28818	Rbm7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RBM7	MGD	MGI:1914260
Macaca mulatta	RBM7	VGNC	VGNC:101388
Rattus norvegicus	RBM7	RGD	RGD:1308017
Others	RBM7	NCBI