ING2 - inhibitor of growth family member 2 Gene

Also Known as ING1L; p33ING2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3622

About ING2

Cytogenetic location: 4q35.1 Genomic coordinates (GRCh38): 4:183,505,058-183,512,429 (from NCBI)

This gene has 2 transcripts (splice variants), 206 orthologues and 4 paralogues. Ubiquitous expression in ovary (RPKM 10.5), adrenal (RPKM 8.4) and 25 other tissues.

Summary

This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of Histone Acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and Apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

ING2 Products (2)

mRNA Protein Name
NM_001291959.2 NP_001278888.1 inhibitor of growth protein 2 isoform 2
NM_001564.4 NP_001555.1 inhibitor of growth protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
15243141 GOA
enables methylated histone binding IDA
IDA: Inferred from direct assay
16728974 GOA
enables phosphatidylinositol binding IDA
IDA: Inferred from direct assay
16893883 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18334480 GOA
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
18334480 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
18334480 GOA
involved in positive regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
18334480 GOA
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15243141 GOA
Cellular Component GO Annotation Evidence References Source
part of CCAAT-binding factor complex IDA
IDA: Inferred from direct assay
15243141 GOA
part of Sin3-type complex IDA
IDA: Inferred from direct assay
16387653 GOA
located in nucleus IDA
IDA: Inferred from direct assay
15243141 GOA
located in nucleus IMP
IMP: Inferred from mutant phenotype
25578879 GOA
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
25578879 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ING2 Protein Structure

ING

ING: Inhibitor of growth proteins N-terminal histone-binding (27 - 124)

PHD

PHD: PHD-finger (214 - 259)

  • 0
  • 100
  • 200
  • 280 a.a.
Protein Preferred Names Protein Names

inhibitor of growth protein 2

  • ING1Lp

ING2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ING2 Q9H160 SIN3A Homo sapiens Q96ST3
Anti Tag CoIP
33961781
Intra
ING2 Q9H160 SIN3A Homo sapiens Q96ST3
Anti Bait CoIP
20676127
Intra
ING2 Q9H160 SIN3A Homo sapiens Q96ST3
Anti Tag CoIP
28514442
Intra
ING2 Q9H160 PCNA Homo sapiens P12004
Anti Bait CoIP
19730436
Intra
ING2 Q9H160 PCNA Homo sapiens P12004
Pull Down
19730436
Intra
ING2 Q9H160 SMURF1 Homo sapiens Q9HCE7-2
Pull Down
20621832
Intra
ING2 Q9H160 SMURF1 Homo sapiens Q9HCE7-2
Anti Tag CoIP
20621832
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Basal Cell Carcinoma

  • Basal Cell Cancer

  • Basal Cell Neoplasm

  • Basal Cell Carcinoma Of Skin

  • Malignant Basal Cell Tumor

  • Basal Cell Tumor

  • Epithelioma Basal Cell

  • Malignant Basal Cell Neoplasm

  • Rodent Ulcer

  • Carcinoma Basal Cell

  • Neoplasms, Basal Cell

  • Basal Cell Carcinomas

  • Experimental Organism Basal Cell Carcinoma

  • Nodulo-Ulcerative Basal Cell Carcinoma

  • Basalioma

  • Basal Cell Epithelioma Of Skin

  • Bcc - [Basal Cell Carcinoma] Of Skin

  • Rodent Ulcer Of Skin

  • Rodent Ulcer Of Unspecified Site

  • Basal Cell Epithelioma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06808 ING2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06809 ING3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ING2 VGNC VGNC:30195
Canis familiaris ING2 VGNC VGNC:42017
Mus musculus ING2 MGD MGI:1916510
Felis catus ING2 VGNC VGNC:67803
Macaca mulatta ING2 VGNC VGNC:73743
Rattus norvegicus ING2 RGD RGD:1307347
Others ING2 NCBI