Isoprenylated chromone derivatives from the plant endophytic fungus Pestalotiopsis fici

  • J Nat Prod. 2009 Aug;72(8):1482-6. doi: 10.1021/np900308s.
Ling Liu  1 ,  Shuchun Liu ,  Shubin Niu ,  Liangdong Guo ,  Xulin Chen ,  Yongsheng Che
Affiliations
  • 1. Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
PMID: 19618920 DOI: 10.1021/np900308s
Abstract

Pestaloficiols F-L (1-7), new isoprenylated chromone derivatives including one heterodimer (7), have been isolated from a scale-up fermentation extract of the plant endophytic fungus Pestalotiopsis fici. The structures of these compounds were elucidated primarily by NMR and MS methods. The absolute configurations of 1 and 4 were assigned using the modified Mosher method. Compounds 1-3, 5, and 6 displayed inhibitory effects on HIV-1 replication in C8166 cells, whereas 4-7 showed cytotoxic activity against the human tumor cell lines HeLa and MCF7.