GSNOR
S-nitrosoglutathione reductase
S-Nitrosoglutathione reductase (GSNOR) is a member of the alcohol dehydrogenase family (ADH) that regulates the levels of S-nitrosothiols (SNOs) through catabolism of S-nitrosoglutathione (GSNO).
GSNOR reduces the nitric oxide (NO) adduct S-nitrosoglutathione (GSNO), an essential reservoir for NO bioactivity. In plants, GSNOR has been found to be important in resistance to bacterial and fungal pathogens. GSNOR is ubiquitously expressed and catalyzes denitrosylation of GSNO, thereby downregulating protein S-nitrosylation in β-cells.
GSNOR activity appears to be necessary for normal development and fertility under optimal growth conditions.
All Product Categories
-
GSNOR Related Products (7)
- N6022
-
loading...loading...
-
-
Cavosonstat
0 ImagesSynonyms: N91115 -
loading...loading...
-
-
SPL-334
0 ImagesSPL-334 is a potent and selective S-Nitrosoglutathione reductase (GSNOR) inhibitor. SPL-334 causes a significant reduction in the production of Th2 cytokines IL-5 and IL-13 and the levels of the chemokine CCL11 (eotaxin-1) in the airways. SPL-334 can be used in research of allergic airway inflammation. -
loading...loading...
-
-
GSNOR-IN-1
0 ImagesCat. No.: HY-176712GSNOR-IN-1, a prodrug of GSNOR-IN-2 (HY-176275), is a BBB-penetrable S-nitrosoglutathione reductase (GSNOR) inhibitor. GSNOR-IN-1 has significant protective activity against OGD/R-induced injury. GSNOR-IN-1 regulates calcium signaling and synaptic function via Clstn1 S-nitrosation and inhibits neuronal apoptosis. GSNOR-IN-1 significantly reduces infarct volume while improving neurological deficits in ischemic stroke rat models. GSNOR-IN-1 has neuroprotective activity, promising for ischemic stroke research. -
loading...loading...
-
- GSNOR-IN-2
-
loading...loading...
-
-
Cavosonstat (Standard)
0 ImagesCat. No.: HY-109027RCAS No.: 1371587-51-7Synonyms: N91115 (Standard)Cavosonstat (Standard) is the analytical standard of Cavosonstat (HY-109027). This product is intended for research and analytical applications. Cavosonstat (N91115) is an orally active S-nitrosoglutathione reductase (GSNOR) inhibitor. Cavosonstat is a CFTR stabilizer, and can be used for cystic fibrosis research. -
loading...loading...
-
- N6022 (Standard)
-
loading...loading...
-
