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MLF1 (Myeloid leukemia factor 1) Antibody (YA8197)(PBS only)

(Synonyms: myeloid leukemia factor 1; myeloid leukemia factor 1 variant 1; myeloid leukemia factor 1 variant 2; myeloid leukemia factor 1 variant 3)

MLF1 (Myeloid leukemia factor 1) Antibody (YA8197) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MLF1 (Myeloid leukemia factor 1).

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    IHC-P, ICC/IF, FC

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • MLF1 (Myeloid leukemia factor 1) Antibody (YA8197)(PBS only) Product Image
  • MLF1 (Myeloid leukemia factor 1) Antibody (YA8197)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Top Publications Citing

Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
FC Info
FC: Flow Cytometry
Dilution Ratio 1:150-500 1:100-250 1:100

Product Details

Description

MLF1 (Myeloid leukemia factor 1) Antibody (YA8197) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MLF1 (Myeloid leukemia factor 1).

  • Host Mouse
  • Species Reactivity
    Human
  • Calculated Molecular Weight Predicted band size: 30.4 kDa
Immunogen

Full length human recombinant protein of human MLF1 produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus

  • Subcellular Localization

    Cytoplasm,Nucleus,Cell projection, cilium,Cytoplasm, cytoskeleton, cilium basal body

  • Expression


    Tissue_Specificity: Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes

  • Isoforms & Post-Translational Modification

    P58340 has 5 isomers: P58340-1: 30627 Da (predicted); P58340-2: 23117 Da (predicted); P58340-3: 33888 Da (predicted); P58340-5: 27625 Da (predicted); P58340-4: 29095 Da (predicted).
    Phosphorylation is required for binding to YWHAZ

  • Subunit

    Interacts with CENPU

  • SwissProt ID

    P58340

  • Synonyms

    myeloid leukemia factor 1; myeloid leukemia factor 1 variant 1; myeloid leukemia factor 1 variant 2; myeloid leukemia factor 1 variant 3

MLF1 (Myeloid leukemia factor 1) Antibody (YA8197)(PBS only) Related Classifications

Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • MLF1 (Myeloid leukemia factor 1) Antibody (YA8197)(PBS only) Product Image
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  • MLF1 (Myeloid leukemia factor 1) Antibody (YA8197)(PBS only) Product Image