SLC22A7 - solute carrier family 22 member 7 Gene

Also Known as NLT; OAT2; hOAT11

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10864

About SLC22A7

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:43,295,714-43,305,538 (from NCBI)

This gene has 9 transcripts (splice variants), 414 orthologues and 22 paralogues. Biased expression in liver (RPKM 51.8) and kidney (RPKM 19.9).

Summary

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

SLC22A7 Products (2)

mRNA	Protein	Name
NM_006672.3	NP_006663.2	solute carrier family 22 member 7 isoform a
NM_153320.2	NP_696961.2	solute carrier family 22 member 7 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables alpha-ketoglutarate transmembrane transporter activity	IDA IDA: Inferred from direct assay	11327718	GOA
enables organic anion transmembrane transporter activity	IDA IDA: Inferred from direct assay	11327718	GOA
enables organic anion transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	21446918	GOA
enables prostaglandin transmembrane transporter activity	IDA IDA: Inferred from direct assay	11907186	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15846844	GOA
enables transmembrane transporter activity	IDA IDA: Inferred from direct assay	18216183	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in alpha-ketoglutarate transport	IDA IDA: Inferred from direct assay	11327718	GOA
involved in prostaglandin transport	IDA IDA: Inferred from direct assay	11907186	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	25904762	GOA
located in basal plasma membrane	IDA IDA: Inferred from direct assay	35307651	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	25904762	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18216183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC22A7 Protein Structure

MFS_1

0
100
200
300
400
500
548 a.a.

Protein Preferred Names	Protein Names
solute carrier family 22 member 7	hOAT2

Related Diseases

Diseases	Alias
Gout	Gouty Arthritis Articular Gout Gouty Arthropathy Arthritis, Gouty Arthritis Gouty Idiopathic Gout Idiopathic Gout, Unspecified Site Gouty Bursitis Uratic Arthritis Gout Nos Gouty Gouty Diathesis
Bilirubin Metabolic Disorder	Hyperbilirubinemia Hereditary Hyperbilirubinemia Hyperbilirubinemia, Hereditary Hyperbilirubinaemia
Glucosephosphate Dehydrogenase Deficiency	G6pd Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency Deficiency Of Glucose-6-Phosphate Dehydrogenase Glucose 6 Phosphate Dehydrogenase Deficiency Deficiency Of G-6pd G6pdd

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS13079	SLC22A7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22036	Slc22a7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28553	Slc22a7 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC22A7	RGD	RGD:621699
Canis familiaris	SLC22A7	VGNC	VGNC:57234
Mus musculus	SLC22A7	MGD	MGI:1859559
Bos taurus	SLC22A7	VGNC	VGNC:34731
Felis catus	SLC22A7	VGNC	VGNC:65246
Macaca mulatta	SLC22A7	VGNC	VGNC:83467
Others	SLC22A7	NCBI