SALL3 - spalt like transcription factor 3 Gene

Also Known as ZNF796

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27164

About SALL3

Cytogenetic location: 18q23 Genomic coordinates (GRCh38): 18:78,979,818-78,998,969 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 196 orthologues and 14 paralogues. Biased expression in brain (RPKM 1.5), prostate (RPKM 0.7) and 2 other tissues.

Summary

This gene encodes a sal-like C2H2-type zinc-finger protein, and belongs to a family of evolutionarily conserved genes found in species as diverse as Drosophila, C. elegans, and vertebrates. Mutations in some of these genes are associated with congenital disorders in human, suggesting their importance in embryonic development. This protein binds to DNA Methyltransferase 3 alpha (DNMT3A), and reduces DNMT3A-mediated CpG island methylation. It is suggested that silencing of this gene, resulting in acceleration of DNA methylation, may have a role in oncogenesis. [provided by RefSeq, Oct 2011]

SALL3 Products (1)

mRNA	Protein	Name
NM_171999.4	NP_741996.2	sal-like protein 3

SALL3 Protein Structure

zf-H2C2_2

zf-C2H2_4

zf-H2C2_2

0
200
400
600
800
1000
1200
1300 a.a.

Protein Preferred Names	Protein Names
sal-like protein 3	C2H2 zinc finger protein SALL3

Related Diseases

Diseases	Alias
Ivic Syndrome	Oculootoradial Syndrome Radial Ray Defects, Hearing Impairment, External Ophthalmoplegia, And Thrombocytopenia IVIC Instituto Venezolano De Investigaciones Cientificas Syndrome Oculo-Oto-Radial Syndrome Oors
Duane-Radial Ray Syndrome	Okihiro Syndrome DRRS Dr Syndrome Duane Anomaly With Radial Ray Abnormalities And Deafness Acrorenoocular Syndrome Acrorenocular Syndrome Duane Anomaly With Radial Abnormalities And Deafness Acro-Renal-Ocular Syndrome
Ureteral Benign Neoplasm	Neoplasm Of Ureter Ureteral Tumor Cancer Of The Ureter Malignant Tumour Of Ureter Ureteric Cancer Primary Malignant Neoplasm Of Ureter
Townes-Brocks Syndrome	Townes Syndrome Renal-Ear-Anal-Radial Syndrome Anus, Imperforate, With Hand, Foot And Ear Anomalies Imperforate Anus-Hand, Foot And Ear Anomalies Syndrome Rear Syndrome Sensorineural Deafness With Imperforate Anus And Hypoplastic Thumbs Tbs Deafness, Sensorineural, With Imperforate Anus And Hypoplastic Thumbs Imperforate Anus With Hand, Foot And Ear Anomalies Anal-Ear-Renal-Radial Malformation Syndrome Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome Imperforate Anus-Hand And Foot Anomalies Syndrome Sensorineural Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome Sensorineural Hearing Loss With Imperforate Anus And Hypoplastic Thumbs
Chromosome 18q Deletion Syndrome	18q- Syndrome Monosomy 18q Deletion Of Long Arm Of Chromosome 18 Chromosome 18q- Syndrome Deletion 18q 18q Deletion Syndrome Distal 18q Deletion Syndrome Chromosome 18 Long Arm Deletion Syndrome Chromosome 18q Monosomy Del Syndrome Chromosome 18 Deletion Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS12419	SALL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SALL3	RGD	RGD:1310232
Macaca mulatta	SALL3	VGNC	VGNC:76967
Mus musculus	SALL3	MGD	MGI:109295
Felis catus	SALL3	VGNC	VGNC:64858
Bos taurus	SALL3	VGNC	VGNC:106912
Canis familiaris	SALL3	VGNC	VGNC:49643
Others	SALL3	NCBI