INTS3 - integrator complex subunit 3 Gene

Also Known as INT3; SOSSA; SOSS-A; C1orf60; C1orf193

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 65123

About INTS3

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,728,050-153,774,808 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele and 200 orthologues. Ubiquitous expression in testis (RPKM 20.6), ovary (RPKM 17.9) and 25 other tissues.

Summary

The protein encoded by this gene can form a complex with human single-strand DNA binding proteins 1 or 2 (hSSB1 and hSSB2) and Other proteins to mediate genome stability and the DNA damage response. The encoded protein is also part of a multiprotein complex that interacts with the C-terminal domain of RNA polymerase II large subunit to help regulate processing of U1 and U2 small nuclear RNAs. [provided by RefSeq, May 2016]

INTS3 Products (2)

mRNA	Protein	Name
NM_001324475.2	NP_001311404.1	integrator complex subunit 3
NM_023015.5	NP_075391.3	integrator complex subunit 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16239144	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	19683501	GOA
involved in DNA repair	IMP IMP: Inferred from mutant phenotype	19605351	GOA
involved in double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	19683501	GOA
involved in mitotic G2/M transition checkpoint	IDA IDA: Inferred from direct assay	19683501	GOA
involved in mitotic G2/M transition checkpoint	IMP IMP: Inferred from mutant phenotype	19683501	GOA
involved in response to ionizing radiation	IMP IMP: Inferred from mutant phenotype	19605351	GOA
involved in snRNA processing	IDA IDA: Inferred from direct assay	16239144	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of SOSS complex	IDA IDA: Inferred from direct assay	18449195	GOA
part of SOSS complex	IPI IPI: Inferred from physical interaction	19683501	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23904267	GOA
part of integrator complex	IDA IDA: Inferred from direct assay	16239144	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19683501	GOA
located in site of double-strand break	IDA IDA: Inferred from direct assay	19683501	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INTS3 Protein Structure

Ints3

0
200
400
600
800
1042 a.a.

Protein Preferred Names	Protein Names
integrator complex subunit 3	SOSS complex subunit A

INTS3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	INTS3	Q68E01	ZBTB14	Homo sapiens	O43829	Validated Y2H	25416956
Intra	INTS3	Q68E01	ZBTB14	Homo sapiens	O43829	Y2H Array	25416956
Intra	INTS3	Q68E01	NABP2	Homo sapiens	Q9BQ15	Anti Bait CoIP	19683501
Intra	INTS3	Q68E01	NABP2	Homo sapiens	Q9BQ15	Pull Down	19683501
Intra	INTS3	Q68E01	NABP2	Homo sapiens	Q9BQ15	GMS	19683501
Intra	INTS3	Q68E01	INIP	Homo sapiens	Q9NRY2	Pull Down	19683501
Intra	INTS3	Q68E01	INIP	Homo sapiens	Q9NRY2	GMS	19683501
Intra	INTS3	Q68E01	INIP	Homo sapiens	Q9NRY2	Anti Bait CoIP	19683501
Intra	INTS3	Q68E01	NABP1	Homo sapiens	Q96AH0	Pull Down	19683501
Intra	INTS3	Q68E01	NABP1	Homo sapiens	Q96AH0	Anti Bait CoIP	19683501
Intra	INTS3	Q68E01	NBN	Homo sapiens	O60934	Pull Down	19683501

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Gand Syndrome	Mrd18 GAND Mental Retardation, Autosomal Dominant 18 Autosomal Dominant Non-Syndromic Intellectual Disability 18 Autosomal Dominant Intellectual Developmental Disorder 18 Autosomal Dominant Mental Retardation 18

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-133702	Aniline-piperazine-C3-NH-Boc		/	Unkown
HY-RS06855	INTS3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	INTS3	VGNC	VGNC:62944
Bos taurus	INTS3	VGNC	VGNC:30229
Macaca mulatta	INTS3	VGNC	VGNC:73659
Mus musculus	INTS3	MGD	MGI:2140050
Canis familiaris	INTS3	VGNC	VGNC:42052
Rattus norvegicus	INTS3	RGD	RGD:1304593
Others	INTS3	NCBI